A Mussel-Inspired Conductive, Self-Adhesive, and Self-Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics
A Mussel-Inspired Conductive, Self-Adhesive, and Self-Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics
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一种受贻贝启发的导电、自粘、可自修复的坚韧水凝胶，可用作细胞刺激器和可植入生物电子学
DOI：
10.1002/smll.201601916
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发表时间：
2017-01-11
期刊：
影响因子：
13.3
通讯作者：
Yuan, Huipin
中科院分区：
文献类型：
--
作者：
Han, Lu;Lu, Xiong;Yuan, Huipin
此外，自愈合性，一个迷人的自然组织的特性，也是导电水凝胶的必要属性，特别是对于那些应用于自愈合电子皮肤和生物电极。自修复性水凝胶可以在损伤后进行自我修复，恢复其原有的结构和性能，从而提高其功能寿命期间的可靠性和安全性。[11]通过在水凝胶网络中引入动态和可逆键，包括疏水相互作用、主-客体相互作用和氢键，设计和构建了自愈合水凝胶。[11b已经开发了几种导电和可愈合的水凝胶，例如聚吡咯/琼脂糖基水凝胶[12 a，B]，然而，这些水凝胶的机械韧性与天然组织相比不强。[13]联合收割机是一项坚韧的工作，结合到导电水凝胶的优异的机械性能和自我修复的性质，除了上述功能，另一个理想的功能，缺乏在以前的报告导电水凝胶的生物医学设备是自我修复。例如，当穿戴或附着到皮肤上时，不良的粘附性导致电子设备与柔软的人体之间的界面分层。一种替代方案是使用额外的胶带，例如聚丙烯酸酯粘合剂、透明胶带和聚碳酸酯粘合剂。
In addition, self-healability, a fascinating characteristic of the natural tissues, is also a necessary property of conductive hydrogels, especially for those applied in self-healing electronic skins and bioelectrodes. Self-healable hydrogels can repair themselves in response to damage and recover their original structures and properties, consequently improve the reliability and safety during their functional lifetimes.[11] Selfhealable hydrogel is designed and constructed by introducing dynamic and reversible bonds, including hydrophobic interactions, host–guest interactions, and hydrogen bonds in the hydrogel networks.[11b, 12] Several conductive and healable hydrogels such as polypyrrole/agarose-based hydrogels,[12a, b] have been already developed, however, these hydrogels are not mechanically tough to be comparable with natural tissues.[13] It is a tough job to combine the both outstanding mechanical property and self-healable property into a conductive hydrogel.Besides the aforementioned functions, another desirable feature missing in previously reported conductive hydrogels for biomedical devices is self-adhesiveness. For example, when worn or attached onto skin, the poor adhesiveness results in interface delamination between the electronic devices and the soft human body. An alternative is to use additional adhesive tapes, such as polyacrylate adhesives, scotch tapes, and