Leptin regulation of neuronal excitability and cognitive function.
Leptin regulation of neuronal excitability and cognitive function.
复制标题
DOI：
10.1016/j.coph.2007.10.006
复制
发表时间：
2007-12
影响因子：
4
通讯作者：
Harvey, Jenni
中科院分区：
文献类型：
--
作者：
Harvey, Jenni
瘦素是一种由脂肪细胞产生的激素，它向下丘脑的特定区域提供控制能量稳态的信号。然而，过去十年的研究不仅揭示了瘦素受体在中枢神经系统中广泛表达，而且还发现了这种激素在大脑中的许多其他功能。特别是，有证据表明瘦素通过激活和运输几个脑区域的特定钾通道来影响神经元的兴奋性。瘦素引起的神经元兴奋性改变与食物摄入、奖励行为和抗惊厥作用的调节有关。许多研究也发现了瘦素在认知过程中的作用，包括激活边缘结构中的瘦素受体，如海马体。事实上，瘦素影响海马依赖的学习和记忆，最近瘦素被证明具有抗抑郁的特性。瘦素这些新作用的特征为这种激素在健康和疾病中调节多种神经元功能的作用提供了有价值的见解。
Leptin, a hormone produced by adipocytes, provides signals to specific regions of the hypothalamus to control energy homeostasis. However, the past decade of research has not only revealed that leptin receptors are widely expressed in the CNS, but has also identified numerous additional functions for this hormone in the brain. In particular, there is evidence that leptin influences neuronal excitability via the activation as well as trafficking of specific potassium channels in several brain regions. Leptin-induced alterations in neuronal excitability have been implicated in the regulation of food intake, reward behaviour and anti-convulsant effects. A number of studies have also identified a role for leptin in cognitive processes that involve activation of leptin receptors in limbic structures, such as the hippocampus. Indeed, leptin influences hippocampal-dependent learning and memory, and more recently leptin has been shown to have anti-depressant properties. Characterisation of these novel actions of leptin is providing valuable insights into the role of this hormone in the regulation of diverse neuronal functions in health and disease.
登录
查看更多内容
影响因子：
4.7
作者：
Durakoglugil M;Irving AJ;Harvey J
通讯作者：
Harvey J
影响因子：
3.3
作者：
Li, XL;Aou, S;Hori, T
通讯作者：
Hori, T
影响因子：
11.4
作者：
Ning, Ke;Miller, Lisa C.;Ashford, Michael L. J.
通讯作者：
Ashford, Michael L. J.
影响因子：
3
作者：
Oomura, Y.;Hori, N.;Sasaki, K.
通讯作者：
Sasaki, K.
影响因子：
2.4
作者：
Mirshamsi S;Laidlaw HA;Ning K;Anderson E;Burgess LA;Gray A;Sutherland C;Ashford ML
通讯作者：
Ashford ML