Development of gliomas: potential role of asymmetrical cell division of neural stem cells
Development of gliomas: potential role of asymmetrical cell division of neural stem cells
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DOI：
10.1016/s1470-2045(04)01531-1
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发表时间：
2004-08-01
期刊：
影响因子：
51.1
通讯作者：
Wion, D
中科院分区：
文献类型：
--
作者：
Berger, F;Gay, E;Wion, D
不对称细胞分裂是产生具有不同增殖和分化命运的两个子细胞的机制。它主要发生在发育和成体干细胞中。越来越多的证据表明，肿瘤细胞来自正常干细胞的转化。在这里，我们提出干细胞的不对称有丝分裂潜能与迁移性肿瘤祖细胞的产生有关。将这种推测性模型应用于胶质瘤提出肿瘤起始干细胞驻留的位点是惰性的并且与肿瘤块不同，并且意味着肿瘤块被来自这些临床沉默区域的新的迁移肿瘤细胞不断补充。这一假说为我们无法治愈胶质母细胞瘤提供了解释，并指出不对称分裂是一个新的潜在治疗靶点。
Assymmetrical cell division is a mechanism that gives rise to two daughter cells with different proliferative and differentiative fates. It occurs mainly during development and in adult stem cells. Accumulating evidence suggests that tumour cells arise from the transformation of normal stem cells. Here, we propose that the assymmetrical mitosis potential of stem cells is associated with the generation of migrating tumour progenitors. Application of this speculative model to glioma proposes that the sites where tumour-initiating stem cells reside are indolent and distinct from the tumour mass, and implies that the tumour mass is continuously replenished with new migrating tumour cells from these clinically silent regions. This hypothesis offers explanations for our inability to cure glioblastoma and points to asymmetrical division as a new potential therapeutic target.