Administration of antibody to the lung protects mice against pneumonic plague
Administration of antibody to the lung protects mice against pneumonic plague
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DOI：
10.1128/iai.74.5.3068-3070.2006
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发表时间：
2006-05-01
影响因子：
3.1
通讯作者：
Titball, RW
中科院分区：
文献类型：
--
作者：
Hill, J;Eyles, JE;Titball, RW
在肺鼠疫模型中，肺内递送对鼠疫耶尔森氏菌LcrV和F1抗原具有特异性的雾化单克隆抗体保护小鼠。这些数据支持使用吸入抗体作为鼠疫的快速作用的暴露后治疗。
Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.