Male genital tract compartmentalization of human immunodeficiency virus type 1 (HIV)
Male genital tract compartmentalization of human immunodeficiency virus type 1 (HIV)
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DOI：
10.1089/aid.2007.0115
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发表时间：
2008-04-01
影响因子：
1.5
通讯作者：
Krieger, John N.
中科院分区：
文献类型：
--
作者：
Diem, Kurt;Nickle, David C.;Krieger, John N.
我们目前的系统发育证据支持HIV感染男性的血液（外周血单核细胞或血浆）和多个泌尿生殖系统部位之间的病毒区室化。评价的5名受试者中有4名表现出泌尿生殖道标本（组织或液体）和至少一种血液类别之间的病毒序列区室化。在5名男性中的4名中检测到HIV序列从血液迁移到泌尿生殖道，在第5名中检测到从泌尿生殖道迁移到血液，在1名男性中观察到两个隔间之间的交叉迁移。这些观察结果在27例男性泌尿生殖道分区研究的报告病例中增加了5例额外病例，研究了先前未评价的手术样本/标本，并进一步证明血液和生殖道之间的艾滋病毒流动受到限制。因此，我们的研究结果对于了解抗逆转录病毒治疗的长期反应，疫苗的设计以及艾滋病毒的性传播非常重要。
We present phylogenetic evidence supporting viral compartmentalization between the blood ( peripheral blood mononuclear cells or plasma) and multiple genitourinary sites in HIV-infected men. Four of the five subjects evaluated demonstrated compartmentalization of viral sequences between urogenital tract specimens ( tissue or fluid) and at least one blood category. HIV sequence migration from blood to urogenital tract was detected in four of five men, with migration from urogenital tract to blood in the fifth, and cross migration between both compartments noted in one man. These observations add 5 additional cases to the 27 total reported cases in which male urogenital tract compartmentalization has been studied, investigate surgical samples/specimens that have not been evaluated previously, and provide further evidence for restricted flow of HIV between the blood and the genital tract. As such, our study findings are important for understanding the long-term response to antiretroviral therapy, the design of vaccines, and the sexual transmission of HIV.