A study of diffusion isotropy in single neurons by using NMR microscopy
A study of diffusion isotropy in single neurons by using NMR microscopy
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DOI：
10.1002/mrm.1910370425
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发表时间：
1997-04-01
影响因子：
3.3
通讯作者：
Blackband, SJ
中科院分区：
文献类型：
--
作者：
Hsu, EW;Aiken, NR;Blackband, SJ
水的表观扩散系数（ADC）的测量在单一的Aaplasia californica神经元通过使用NMR显微镜编码的两个垂直梯度方向。在5个细胞和这些细胞内的50个亚区中，总核和细胞质隔室的平均ADC的比较显示，在大多数情况下，扩散测量之间没有显着差异。由于各向异性扩散会使ADC依赖于编码方向，因此结果表明，在这些研究中使用的空间和时间分辨率下，这些单个神经元中的ADC是各向同性的。因此，单个标量ADC测量足以表征这些单元中的ADC，从而减少ADC为各向异性时所需的采集时间和测量复杂度。
The apparent diffusion coefficient (ADC) of water was measured in single Aplysia californica neurons by using NMR microscopy encoded in each of two perpendicular gradient directions. Comparisons of the mean ADCs of the gross nuclear and cytoplasmic compartments in five cells, and 50 subregions within these cells, showed no significant difference between the diffusion measurements in the majority of cases. Since anisotropic diffusion would make the ADC dependent on the encoding direction, the results indicate that the ADC in these single neurons is isotropic at the spatial and temporal resolutions used in these studies. Consequently, a single scalar ADC measurement is sufficient for characterizing the ADC in these cells, hence reducing the acquisition time and measurement complexity that would have been required had the ADC been anisotropic.