Capsule-Endoscopic Findings of Ulcerative Colitis Patients
Capsule-Endoscopic Findings of Ulcerative Colitis Patients
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DOI：
10.1159/000333086
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发表时间：
2011-01-01
期刊：
影响因子：
3.2
通讯作者：
Nakajima, Atsushi
中科院分区：
文献类型：
--
作者：
Higurashi, Takuma;Endo, Hiroki;Nakajima, Atsushi
背景/目的：溃疡性结肠炎(UC)是一种以弥漫性黏膜炎症为特征的慢性炎症性肠病，传统认为局限于结直肠。虽然最近在UC病例中也有一些胃十二指肠病变的报道，但总的来说，UC的小肠病变被认为是极其罕见的。本研究的目的是通过胶囊内窥镜检查UC患者的小肠。方法：研究对象为23名有文献记载的UC患者和23名对照志愿者。比较两组患者小肠病变的发生率、平均每位患者的小肠病变个数和胶囊内窥镜评分。结果：23例UC患者中，13例(57%)表现为小肠病变，8例(35%)表现为糜烂。两组在小肠病变(p<；0.001)和糜烂(p=0.009)的发生率上有显著差异。胶囊内窥镜评分与UC疾病活动性指数相关(r=0.718，p<；0.001)。结论：与健康志愿者相比，这是第一次进行胶囊-内窥镜检查UC患者的小肠受累。由此得出结论：UC是一种慢性炎症性肠病，也可累及小肠。版权所有(C)2011 S.Karger AG，巴塞尔
Background/Aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by diffuse mucosal inflammation, traditionally regarded as being limited to the colorectum. Although several gastroduodenal lesions have also been reported recently in cases of UC, in general, small-bowel lesions in UC are believed to be extremely rare. The aim of this study was to examine the small bowel by capsule endoscopy in patients with UC. Methods: The study was conducted in 23 well-documented UC patients and 23 control volunteers. The frequency of small-bowel lesions, the number of small-bowel lesions per patient and the capsule endoscopy score were comparatively evaluated between the two groups. Results: Of the 23 UC patients, 13 (57%) showed small-bowel lesions, and 8 (35%) had erosions. There were significant differences in the frequency of the small-bowel lesions (p < 0.001) and erosions (p = 0.009) between the two groups. The capsule endoscopy score was correlated with the UC disease activity index (r = 0.718, p < 0.001). Conclusions: This is the first capsule-endoscopic study conducted to examine the small-bowel involvement in UC patients as compared with the healthy volunteers. It was concluded that UC, a chronic inflammatory bowel disease, can also involve the small bowel. Copyright (C) 2011 S. Karger AG, Basel