Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer - From the Danish "MALOVA" Ovarian Cancer Study
Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer - From the Danish "MALOVA" Ovarian Cancer Study
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DOI：
10.1016/j.ygyno.2007.03.043
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发表时间：
2007-08-01
影响因子：
4.7
通讯作者：
Hogdall, Claus K.
中科院分区：
文献类型：
--
作者：
Hogdall, Estrid V. S.;Christensen, Lise;Hogdall, Claus K.
目标。目的：测定774例卵巢上皮性肿瘤患者肿瘤组织中WT1的表达水平。其次，评估WT1组织表达水平是否与临床病理参数相关，最后探讨WT1表达水平在卵巢癌（OC）患者中的预后价值。利用组织阵列技术，我们分析了186例低恶性潜能肿瘤（LMP）患者（160例ⅰ期、5例ⅱ期和21例ⅲ期）和560例OC患者（160例ⅰ期、60例ⅱ期、289例ⅲ期和51例ⅳ期）组织中WT1的表达水平。使用10%作为WT1过表达的截止水平，分别有19%的LMPs和17%的癌被发现呈阳性。与其他组织学亚型相比，浆液亚型的阳性肿瘤比例更高(p
Objectives. To determine the WT1 expression level in tumor tissues from 774 women with an epithelial ovarian tumor. Secondly, to evaluate whether WT1 tissue expression levels correlate with clinico-pathological parameters and finally to investigate the prognostic value of WT1 expression levels in ovarian cancer (OC) patients.Methods. Using tissue array we analyzed the WT1 expression level in tissues from 186 women with Low Malignant Potential tumors (LMP) (160 stage I, 5 stage II and 21 stage III) and 560 OC patients (160 stage I, 60 stage II, 289 stage III and 51 stage IV).Results. Using 10% as cut-off level for WT1 overexpression an overall of 19% LMPs and 17% carcinomas, respectively, were found positive. For both, a higher proportion of positive tumors was found in the serous subtype compared to other histological subtypes (p