EFFECTS OF SELECTIVE ACTIVATION OR BLOCKADE OF THE HISTAMINE H3 RECEPTOR ON SLEEP AND WAKEFULNESS
EFFECTS OF SELECTIVE ACTIVATION OR BLOCKADE OF THE HISTAMINE H3 RECEPTOR ON SLEEP AND WAKEFULNESS
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DOI：
10.1097/00002826-199202001-00154
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发表时间：
1991-12
影响因子：
1
通讯作者：
J. Monti;H. Jantos;M. Boussard;H. Altier;C. Orellana;S. Olivera
中科院分区：
文献类型：
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作者：
J. Monti;H. Jantos;M. Boussard;H. Altier;C. Orellana;S. Olivera
在植入电极进行慢性睡眠记录的大鼠中，比较了组胺H3受体激动剂（R）-α-甲基组胺与组胺H3拮抗剂硫代哌丁胺的作用。将（R）-α-甲基组胺（1.0-4.0微克）双侧注射到乳头前区，在该区域检测到组胺免疫反应神经元，增加了慢波睡眠，而觉醒和REM睡眠则减少。当腹膜内给予（R）-α-甲基组胺（1.0-8.0 mg/kg）时，未观察到显著作用。觉醒增加，慢波睡眠和REM睡眠减少。硫代哌丁胺（4.0 mg/kg）预处理可预防（R）-α-甲基组胺（2.0 mg）对慢波睡眠和觉醒的影响。我们的研究结果进一步支持组胺在清醒状态的控制中的积极作用。
The effects of the histamine H3 receptor agonist, (R)-alpha-methylhistamine were compared with those of the histamine H3 antagonist, thioperamide, in rats implanted with electrodes for chronic sleep recordings. (R)-alpha-Methylhistamine (1.0-4.0 micrograms) injected bilaterally into the premammillary area where histamine immunoreactive neurons have been detected increased slow wave sleep, whereas wakefulness and REM sleep were decreased. No significant effects were observed when (R)-alpha-methylhistamine (1.0-8.0 mg/kg) was administered i.p. Thioperamide (1.0-4.0 mg/kg i.p.) increased wakefulness and decreased slow wave sleep and REM sleep. Pretreatment with thioperamide (4.0 mg/kg) prevented the effects of (R)-alpha-methylhistamine (2.0 micrograms) on slow wave sleep and wakefulness. Our results further support an active role for histamine in the control of the waking state.