Maximal gene number maintainable by stochastic correction - The second error threshold
Maximal gene number maintainable by stochastic correction - The second error threshold
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DOI：
10.1016/j.jtbi.2016.02.007
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发表时间：
2016-09-21
影响因子：
2
通讯作者：
Kun, Adam
中科院分区：
文献类型：
--
作者：
Hubai, Andras G.;Kun, Adam
对于生命起源的先有鸡还是先有蛋的问题--艾根悖论，目前还没有普遍的解决方案：精确的复制和长的基因组都不可能在彼此事先建立起来的情况下进化出来。但是，一系列小的、单独复制的基因可能会提供一个解决方案，前提是多级选择有助于整体的生存。这样的系统必须克服两个关键的困难：基因的非同步复制，以及它们在分裂时随机分配到子细胞（更高层次选择的单位）中。在这里，我们发现，使用随机校正模型框架，大量（tau>= 90）的基因可以共存。此外，该系统可以容忍约10%的基因之间的复制率不对称（竞争）。在此基础上，我们提出了一个似是而非的（和可测试的!）关于新基因如何被整合到早期生命系统中的一个设想：一条通往复杂代谢的途径。(C)2016爱思唯尔有限公司版权所有
There is still no general solution to Eigen's Paradox, the chicken-or-egg problem of the origin of life: neither accurate copying, nor long genomes could have evolved without one another being established beforehand. But an array of small, individually replicating genes might offer a workaround, provided that multilevel selection assists the survival of the ensemble. There are two key difficulties that such a system has to overcome: the non-synchronous replication of genes, and their random assortment into daughter cells (the units of higher-level selection) upon fission. Here we find, using the Stochastic Corrector Model framework, that a large number (tau >= 90) of genes can coexist. Furthermore, the system can tolerate about 10% replication rate asymmetry (competition) among the genes. On this basis, we put forward a plausible (and testable!) scenario for how novel genes could have been incorporated into early living systems: a route to complex metabolism. (C) 2016 Elsevier Ltd. All rights reserved.