SABBAC:: online structural alphabet-based protein backbone reconstruction from alpha-carbon trace
SABBAC:: online structural alphabet-based protein backbone reconstruction from alpha-carbon trace
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DOI：
10.1093/nar/gkl289
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发表时间：
2006-07-01
影响因子：
14.9
通讯作者：
Tuffery, Pierre
中科院分区：
文献类型：
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作者：
Maupetit, Julien;Gautier, R.;Tuffery, Pierre
SABBAC是一项致力于从α-碳痕迹重建蛋白质骨架的在线服务。它是基于从缩小的文库中提取的片段的组装，该文库是从隐藏的马尔可夫模型派生的结构字母表中的蛋白质痕迹的编码中选择的。碎片的组装是通过使用基于能量的评分的贪婪算法来实现的。阿尔法-碳坐标仍未受到影响。SABBAC只是定位缺失的主干原子，不进行进一步的细化。从我们的测试来看，SABBAC的性能与其他类似的在线方法相当或更好，并且对α-碳坐标的偏差具有很强的鲁棒性。可以在http://bioserv.rpbs.jussieu.fr/SABBAC.html.上访问它
SABBAC is an on-line service devoted to protein backbone reconstruction from alpha-carbon trace. It is based on the assembly of fragments taken from a library of reduced size, selected from the encoding of the protein trace in a hidden Markov model-derived structural alphabet. The assembly of the fragments is achieved by a greedy algorithm, using an energy-based scoring. Alpha-carbon coordinates remain unaffected. SABBAC simply positions the missing backbone atoms, no further refinement is performed. From our tests, SABBAC performs equal or better than other similar on-line approach and is robust to deviations on the alpha-carbon coordinates. It can be accessed at http://bioserv.rpbs.jussieu.fr/SABBAC.html.