Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure.
Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure.
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DOI：
10.14814/phy2.13497
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发表时间：
2017-11
影响因子：
2.5
通讯作者：
Sugimachi M
中科院分区：
文献类型：
--
作者：
Zheng C;Li M;Kawada T;Inagaki M;Uemura K;Sugimachi M
液体潴留是慢性心力衰竭（CHF）患者住院率高的主要原因。由于缺乏对CHF患者液体摄入调节及其后果的了解，目前的指南没有为液体管理提供明确的指导。使用CHF大鼠模型，我们研究了改变饮酒行为和探索液体管理策略。通过结扎8周龄雄性Sprague-道利大鼠的冠状动脉左前降支诱导CHF。使用定制设计的液滴计数和反馈控制系统来记录和调节饮酒行为。在诱导心肌梗死（MI）后的第一个月，我们观察到，在饮酒事件之间的间隔时间延长的动物中，自发的单位饮酒量（PDV）显著增加。此外，早期PDV与MI后寿命之间存在显著负相关（r =-0.907; P < 0.001）。此外，与允许自由饮酒的动物相比，调节CHF大鼠的饮酒行为，包括频繁饮用小PDV，显著增强了血液动力学并防止了心脏重塑，180天存活率显著提高（50% vs. 36%; P < 0.01）。动态PDV变化的结果，MI后，表明受损的口渴机制与CHF大鼠的液体平衡的感知和调节。这些结果表明，增加饮酒频率，小PDV，可能有利于预防CHF心功能不全的进展。
Fluid retention is the main reason for the high hospitalization rate among patients with chronic heart failure (CHF). Given the lack of knowledge about fluid intake regulation and its consequences in patients with CHF, current guidelines do not provide clear direction for fluid management. Using a rat model of CHF, we investigated altering drinking behaviors and explored fluid management strategies. CHF was induced by ligating the left anterior descending coronary arteries in 8‐week‐old, male, Sprague‐Dawley rats. A custom‐designed drop counting and feedback control system was used to record and modulate drinking behaviors. During the first month after an induced myocardial infarction (MI), we observed that the spontaneous per drinking volume (PDV) was significantly increased in animals with prolonged intervals between drinking episodes. In addition, there was a significant inverse correlation between the early PDV and the post‐MI lifespan (r = −0.907; P < 0.001). Moreover, modulating the drinking behavior of rats with CHF to involve frequent drinking of small PDVs significantly enhanced hemodynamics and prevented cardiac remodeling, with a significant improvement in the 180‐day survival rate, compared with animals allowed to drink freely (50% vs. 36%; P < 0.01). The results of dynamic PDV changes, after MI, suggest that an impaired thirst mechanism is associated with the sensing and regulating of fluid balance in rats with CHF. These results suggest that increasing the drinking frequency, with small PDVs, may be beneficial to preventing progression of cardiac dysfunction in CHF.