Comparison of remnant-like lipoprotein particles in postmenopausal women with and without coronary artery disease and in men with coronary artery disease.
Comparison of remnant-like lipoprotein particles in postmenopausal women with and without coronary artery disease and in men with coronary artery disease.
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患有和不患有冠状动脉疾病的绝经后女性以及患有冠状动脉疾病的男性中残余样脂蛋白颗粒的比较。
DOI：
10.1016/s0002-9149(01)02115-4
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
H. Ogawa
中科院分区：
文献类型：
--
作者：
H. Fukushima;K. Kugiyama;S. Sugiyama;O. Honda;S. Koide;S. Nakamura;H. Kawano;H. Soejima;S. Miyamoto;M. Yoshimura;T. Sakamoto;H. Ogawa
高甘油三酯血症是绝经后妇女冠状动脉疾病(CAD)的危险因素。这项研究前瞻性地研究了残脂蛋白--一种富含动脉粥样硬化的甘油三酯的脂蛋白--对于血管造影证实的绝经后冠心病妇女是否具有显著的风险和预后价值。用免疫分离法测定了134例绝经后女性冠心病患者(n=56)和非冠心病患者(n=78)的空腹血清残余型脂蛋白胆固醇(RLP-胆固醇)水平。对患有冠心病的妇女进行≤24个月的随访，直到发生以下临床冠状动脉事件：因复发或顽固性心绞痛而再次入院或冠状动脉血运重建、非致命性心肌梗死和心源性死亡。多因素Logistic回归分析显示，高RLP胆固醇水平(>；5.7 mg/dl胆固醇；对照组RLP胆固醇水平分布的第90个百分位数)是独立于低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和其他传统危险因素而出现冠心病的显著危险因素。卡普兰-迈耶分析表明，患有冠心病和RLP胆固醇水平较高的女性发生冠状动脉事件的可能性显著更高(p<；0.001)。在多变量COX风险分析中，高RLP胆固醇水平以及糖尿病和高胆固醇血症是独立于其他危险因素的冠心病女性未来冠状动脉事件的显著预测因素(优势比9.7，95%可信区间1.3至20.3，p=0.02)。总之，RLP胆固醇水平升高是冠心病的一个重要的独立危险因素，并预测绝经后女性冠心病患者未来的冠状动脉事件。
It is known that hypertriglyceridemia is a risk factor of coronary artery disease (CAD) in postmenopausal women. This study prospectively examined whether remnant lipoprotein, an atherogenic triglyceride-rich lipoprotein, may have a significant risk and prognostic values in postmenopausal women with angiographically verified CAD. Remnant-like lipoprotein particles cholesterol (RLP cholesterol) levels in fasting serum were measured in 134 consecutive postmenopausal women with (n = 56) or without (n = 78) CAD by an immunoseparation method. The women with CAD were followed for ≤24 months until occurrence of the following clinical coronary events: readmission or coronary revascularization due to recurrent or refractory angina pectoris, nonfatal myocardial infarction, and cardiac death. Multivariate logistic regression analysis showed that high RLP cholesterol levels (>5.7 mg/dl cholesterol; 90th percentile of the distribution of RLP cholesterol levels in controls) were a significant risk factor for the presence of CAD independent of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and other traditional risk factors. Kaplan-Meier analysis demonstrated that women with CAD and higher RLP cholesterol levels had a significantly higher probability of developing coronary events (p <0.001). In multivariate Cox hazard analysis, high RLP cholesterol levels as well as diabetes and hypercholesterolemia were a significant predictor of future coronary events independent of other risk factors in women with CAD (odds ratio 9.7, 95% confidence intervals 1.3 to 20.3, p = 0.02). In conclusion, increased levels of RLP cholesterol are a significant and independent risk factor of CAD and predict future coronary events in postmenopausal women with CAD.
使用载脂蛋白 B-100 单克隆抗体从人血浆中分离出富含甘油三酯的脂蛋白的载脂蛋白 E 富集组分的特性。
影响因子：
6.5
作者：
Campos,E;Nakajima,K;Tanaka,A;Havel,RJ
通讯作者：
Havel,RJ
影响因子：
158.5
作者：
COLDITZ, GA;WILLETT, WC;HENNEKENS, CH
通讯作者：
HENNEKENS, CH