Causation and Disease: The Henle-Koch Postulates Revisited 1
Causation and Disease: The Henle-Koch Postulates Revisited 1
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发表时间：
1976-05
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通讯作者：
A. Evans
中科院分区：
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作者：
A. Evans
亨利-科赫假设在科赫的时代和后来的发展中被全面审查。本文按时间顺序讨论了病毒性疾病、与癌症和慢性中枢神经系统感染有关的病毒以及慢性疾病的病原体的不断变化的指南。提出了一套急性传染病和慢性疾病的指导方针。强调有必要认识到宿主的作用和宿主反应的范围，有必要在评估疾病中病原体的因果作用时具有良好的生物学意义，并有必要灵活地使我们的指导方针适应新的知识。ImagesFIG。1图。2图。3图。4图。5图。6无花果。7图。8
The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments. The changing guidelines developed for viral diseases, for viruses in relation to cancer and to chronic central nervous system infection, and for causative agents in chronic diseases are discussed chronologically. A set of guidelines for both acute infectious and chronic diseases is presented. The need for recognizing the role of the host and the spectrum of host responses, for sound biologic sense in evaluating causal roles of agents in disease, and for flexibility in adapting our guidelines to new knowledge are emphasized. ImagesFIG. 1FIG. 2FIG. 3FIG. 4FIG. 5FIG. 6FIG. 7FIG. 8