Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects-A Narrative Review of Human and Animal Evidence.
Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects-A Narrative Review of Human and Animal Evidence.
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DOI：
10.3390/bs7010004
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发表时间：
2017-01-19
期刊：
影响因子：
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通讯作者：
Howell A
中科院分区：
文献类型：
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作者：
Harvie M;Howell A
间歇性能量限制（IER）已经成为超重和肥胖人群中控制体重的一种手段，也被正常体重的人所采用，他们希望显著的能量限制能优化他们的健康。本文综述了间歇性和等能量连续能量限制减肥管理超重和肥胖的随机比较。它还总结了人体研究中IER对身体组成、脂肪储存和代谢影响的潜在有益或不利影响，包括正常体重受试者和相关动物实验中的研究。在超重或肥胖个体中进行的6项小型短期（<6个月）研究表明，间歇性能量限制等同于持续限制体重减轻，其中一项研究报告了体脂的更大减少，两项研究报告了响应于IER的HOMA胰岛素抵抗的更大减少，没有明显的危害证据。在正常体重受试者和不同动物模型中进行的研究强调了间歇性能量限制与持续能量限制相比对异位和内脏脂肪储存、脂肪细胞大小、胰岛素抵抗和代谢灵活性的潜在有益和不利影响。IER对超重或肥胖人群，特别是正常体重受试者的长期益处或危害尚不清楚，这是进一步调查的优先事项。
Intermittent energy restriction (IER) has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition, adipose stores and metabolic effects from human studies, including studies amongst normal weight subjects and relevant animal experimentation. Six small short term (<6 month) studies amongst overweight or obese individuals indicate that intermittent energy restriction is equal to continuous restriction for weight loss, with one study reporting greater reductions in body fat, and two studies reporting greater reductions in HOMA insulin resistance in response to IER, with no obvious evidence of harm. Studies amongst normal weight subjects and different animal models highlight the potential beneficial and adverse effects of intermittent compared to continuous energy restriction on ectopic and visceral fat stores, adipocyte size, insulin resistance, and metabolic flexibility. The longer term benefits or harms of IER amongst people who are overweight or obese, and particularly amongst normal weight subjects, is not known and is a priority for further investigation.