Functions and therapeutic potentials of exosomes in osteosarcoma.
Functions and therapeutic potentials of exosomes in osteosarcoma.
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DOI：
10.15212/amm-2022-0024
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发表时间：
2022-10-18
期刊：
影响因子：
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通讯作者：
Li, Shenglong
中科院分区：
文献类型：
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作者：
Yue, Jiaji;Chen, Zhe-Sheng;Li, Shenglong
骨肉瘤是一种原发性骨骼恶性肿瘤，发病率为100万分之2.5。多发于四肢骨骺，早期转移可能性大，进展快，预后差。转移性或复发性骨肉瘤患者的生存率仍然较低，迫切需要新的诊断和治疗方法。外泌体是由多种细胞分泌的直径30-150 nm的细胞外囊泡，广泛存在于各种体液中。外泌体富含蛋白质、核酸和脂质等生物活性成分。外泌体通过细胞间物质交换和信号传导参与许多生理和病理过程。本综述介绍了外泌体在骨肉瘤诊断、预后和治疗方面的新发现。
Osteosarcoma is a primary malignant tumor of the skeleton with the morbidity of 2.5 in 1 million. The regularly on-set is in the epiphysis of the extremities with a high possibility of early metastasis, rapid progression, and poor prognosis. The survival rate of patients with metastatic or recurrent osteosarcoma remains low, and novel diagnostic and therapeutic methods are urgently needed. Exosomes are extracellular vesicles 30-150 nm in diameter secreted by various cells that are widely present in various body fluids. Exosomes are abundant in biologically active components such as proteins, nucleic acids, and lipids. Exosomes participate in numerous physiological and pathological processes via intercellular substance exchange and signaling. This review presents the novel findings of exosomes in osteosarcoma in diagnosis, prognosis, and therapeutic aspects.