Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
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DOI：
10.1002/pros.21234
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发表时间：
2011-02-15
期刊：
影响因子：
--
通讯作者：
Lange EM
中科院分区：
文献类型：
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作者：
Wang Y;Ray AM;Johnson EK;Zuhlke KA;Cooney KA;Lange EM
前列腺癌是美国男性中最常诊断出的非皮肤癌，也是癌症相关死亡的第二大原因。非裔美国男性被诊断出这种疾病和死于该疾病的风险大大增加。最近的全基因组遗传关联研究发现了一些与欧洲血统男性前列腺癌相关的常见单核苷酸遗传多态性 (SNP)。只有少数研究评估了这些基因变异与非裔美国人前列腺癌之间的关联。我们使用逻辑回归模型来评估非裔美国男性前列腺癌与先前报道与欧洲血统男性前列腺癌相关区域的 24 个 SNP 之间的关联。我们发现了前列腺癌与三个染色体 8q24（rs6983561、rs16901979 和 rs7000448）和两个 10q11（rs7904463 和 rs10740051）SNP 之间关联的名义证据（P<0.05）。我们证实了最近的报告，即被确定与欧洲血统男性前列腺癌相关的 8q24 变异也与非裔美国人前列腺癌相关。我们的报告首次发现 MSMB 附近的 SNP 与非裔美国人前列腺癌之间存在关联的证据。值得注意的是，rs7000448 与 NCOA4 中的 rs10761581 存在强连锁不平衡，NCOA4 中的一个 SNP 与附近基因 MSMB 中广泛报道的 SNP rs10993994 与欧洲血统男性的前列腺癌独立相关。
Prostate cancer is the most commonly diagnosed non-skin cancer in men in the United States and the second leading cause of cancer-related mortality. African American men have substantially increased risk of both being diagnosed and dying from the disease. Recent genome-wide genetic association studies have identified a number of common single nucleotide genetic polymorphisms (SNPs) that are associated with prostate cancer in men of European descent. Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans. We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent. We found nominal evidence (P<0.05) for association between prostate cancer and three chromosome 8q24 (rs6983561, rs16901979, and rs7000448) and two 10q11 (rs7904463 and rs10740051) SNPs. We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans. Our report is the first to find evidence of association between SNPs near MSMB and prostate cancer in African Americans. Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.