Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis
Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis
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DOI：
10.1248/bpb.b18-00803
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发表时间：
2019-03-01
影响因子：
2
通讯作者：
Ooi, Kazuya
中科院分区：
文献类型：
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作者：
Goto, Kenji;Hiramoto, Keiichi;Ooi, Kazuya
皮肤干燥是类风湿性关节炎（RA）模型小鼠的一个特征。然而，RA 引起皮肤干燥的机制尚不清楚。我们假设辅助 T (Th)2 和 Th17 细胞介导这一过程。用Th2或Th17细胞抑制剂治疗DBA/1JJmsSlc胶原诱导关节炎的小鼠模型，并评估经表皮失水（TEWL）以及与过敏反应和炎症相关的标志物的表达。与对照小鼠相比，关节炎小鼠模型中的 TEWL 和胸腺基质淋巴细胞生成素、白细胞介素 (IL)-6 和 -17 以及肿瘤坏死因子 (TNF)-α 的血浆水平升高。 Th2细胞抑制剂的施用消除了TEWL、IL-6和TNF-α水平的增加，而Th17细胞抑制剂则逆转了TEWL并降低了IL-17水平。 Th2 和 Th17 细胞有助于诱导皮肤干燥，但机制不同。
Skin dryness is a characteristic of rheumatoid arthritis (RA) model mice. However, the mechanism underlying the induction of dry skin by RA is unclear. We hypothesized that T helper (Th)2 and Th17 cells mediate this process. A mouse model of DBA/1JJmsSlc collagen-induced arthritis was treated with Th2 or Th17 cell inhibitor, and transepidermal water loss (TEWL) and the expression of markers associated with allergic reaction and inflammation were evaluated. TEWL and plasma levels of thymic stromal lymphopoietin, interleukin (IL)-6 and -17, and tumor necrosis factor (TNF)-alpha were increased in the arthritis mouse model compared to that in control mice. Administration of Th2 cell inhibitor abolished the increase in TEWL, IL-6, and TNF-alpha levels, whereas Th17 cell inhibitor reversed TEWL and decreased IL-17 level. Th2 and Th17 cells contribute to the induction of dry skin, but via distinct mechanisms.