Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis.

Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis.
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DOI:
10.1038/bjc.1981.9
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发表时间:
1981-01
影响因子:
8.8
通讯作者:
Smith, D C
Smith, D C
中科院分区:
医学1区
文献类型:
--
作者:
Leake, R E;Laing, L;McArdle, C;Smith, D C

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The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- disease. An earlier observation that RE- primary disease gave rise to distant metastases as first site of recurrence more frequently than did RE+ disease, was not sustained. However, patients with RE+ primary disease had a much reduced chance of dying from cancer within a 3-year period.