Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study.
Altered Regional Gray Matter Volume in Obese Men: A Structural MRI Study.
复制标题
肥胖男性的区域灰质体积改变：一项结构性MRI研究。
DOI：
10.3389/fpsyg.2017.00125
复制
发表时间：
2017
影响因子：
3.8
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang B;Tian X;Tian D;Wang J;Wang Q;Yu C;Li C;Wang J
肥胖与许多健康问题有关，特别是胰岛素抵抗和2型糖尿病。我们以前的研究表明，肥胖男性的眶额皮质（OFC）的神经活动减少，左壳核的活动增加，这可能表明肥胖者的饮食行为改变与功能亢进的纹状体和功能减退的抑制控制有关。因此，我们当前研究的目标是确定肥胖个体的这两个神经系统中的大脑结构是否存在改变。20名肥胖男性（年龄：20-28岁）和20名年龄匹配的瘦男性受试者参与了本研究。在饥饿状态下检测血糖和胰岛素，并基于血液样本进行胰岛素抵抗的稳态模型评估（HOMA-IR）。在这项研究中，我们使用结构MRI和基于体素的形态测量（VBM）方法来研究肥胖受试者的区域结构，并找出胰岛素和大脑结构之间是否存在相关性。结果发现，肥胖男性仅左侧壳核灰质体积（GMV）显著增加，且与体重指数、血浆胰岛素和HOMA-IR呈正相关，壳核是参与胰岛素信号调节的核心区域，壳核GMV异常是胰岛素异常的核心改变。此外，尽管两组在OFC上没有显著差异，但OFC的GMV与饥饿评分呈负相关。结论：壳核结构和功能的改变可能在肥胖和胰岛素异常中起重要作用。
Obesity is associated with a number of health problems, especial insulin resistance and Type 2 diabetes. Our previous study showed that obese males had decreased neural activity in the orbital frontal cortex (OFC) and increased activity in the left putamen, which could indicate altered eating behaviors in obesity related to a hyper-functioning striatum and hypo-functioning inhibitory control. Accordingly, our goal of the current study was to determine whether there are alterations in the brain structures within these two neural systems in obese individuals. Twenty obese men (age: 20–28 years) and 20 age-matched lean male subjects were involved in the current study. Plasma glucose and insulin were tested during hunger state, and homeostasis model assessment of insulin resistance (HOMA-IR) was based on the blood samples. In the study, we used structural MRI and a voxel-based morphometry (VBM) method to investigate regional structures in obese subjects and find out whether there are correlations between the insulin and the brain structures. We found that obese men only showed a significantly increased gray matter volume (GMV) in the left putamen and that the GMV of the left putamen was positively correlated with body mass index, plasma insulin and HOMA-IR. The putamen is a core region participating in insulin signal regulation, and our results showed an abnormal GMV of the putamen is a core alternation in aberrant insulin. Furthermore, the GMV of the OFC was negatively correlated with hunger rating, despite there being no significant difference between the two groups in the OFC. In conclusion, the altered structure and function of the putamen could play important roles in obesity and aberrant insulin.