Mechanical properties of human trabecular bone lamellae quantified by nanoindentation.
Mechanical properties of human trabecular bone lamellae quantified by nanoindentation.
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DOI：
10.3233/thc-1998-65-615
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发表时间：
1998-12
期刊：
影响因子：
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通讯作者：
P. Zysset;X. Guo;C. E. Hoffler;K. E. Moore;S. Goldstein
中科院分区：
文献类型：
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作者：
P. Zysset;X. Guo;C. E. Hoffler;K. E. Moore;S. Goldstein
改善骨质疏松症等骨骼疾病的预防和治疗策略依赖于更好地了解松质骨的机械特性及其对细胞介导的适应过程的影响。骨小梁的机械性能由组成以及结构（骨小梁结构）、微观结构（骨小梁包）和纳米结构（骨小梁）组织决定。密度是小梁结构的机械性能的主要预测因子，并已扩展到织物的概念，以包括结构各向异性，并进一步提高预测能力。QCT和MRI技术的最新进展允许精确评估3D小梁结构，并且结构变化的机械后果可以通过计算方法越来越好地量化。虽然已经使用各种技术对单个骨小梁进行了测试，并获得了对比结果，但对这些计算方法所依赖的骨小梁层的内在力学性能知之甚少。例如，水和矿物质含量对骨组织的弹性、粘性、屈服和后屈服性质具有显著影响。此外，胶原纤维取向影响单个重塑单位的力学。因此，年龄、累积损伤或疾病导致的骨小梁组成和组织的变化可能会降低骨小梁的机械完整性，值得更多关注。本工作的目的是利用纳米压痕技术来量化人体松质骨板的弹性模量和硬度。
Improved preventive and therapeutic strategies for skeletal diseases such as osteoporosis rely on a better understanding of the mechanical properties of trabecular bone and their influence on cell mediated adaptation processes. The mechanical properties of trabecular bone are determined by composition as well as structural (trabecular architecture), microstructural (trabecular packets) and nanostructural (lamellae) organization. Density is the major predictor of the mechanical properties of trabecular structures and has been extended to the concept of fabric to include architectural anisotropy and improve even further the power of prediction. Recent advances in QCT and MRI technologies allow for precise assessment of 3D trabecular architecture and the mechanical consequences of structural changes can be increasingly well quantified by the means of computational methods. While single trabeculae have been tested using various techniques with contrasting results, little is known about the intrinsic mechanical properties of trabecular bone lamellae on which these computational methods rely. For instance, water and mineral content have a significant effect on the elastic, viscous, yield and postyield properties of bone tissue. In addition, collagen fiber orientation affects the mechanics of single remodeling units. Variations in composition and organization determined by age, accumulated damage or disease may therefore reduce the mechanical integrity of trabecular bone and deserve more attention. The aim of this work was to utilize a nanoindentation technique to quantify elastic modulus and hardness of human trabecular bone lamellae.