Chronic lithium chloride infusions: conditioned suppression of food intake and preference.
Chronic lithium chloride infusions: conditioned suppression of food intake and preference.
复制标题
慢性氯化锂输注：条件性抑制食物摄入和偏好。
DOI：
10.1037//0735-7044.97.2.290
复制
发表时间：
1983
影响因子：
1.9
通讯作者：
Goehler,LE
中科院分区：
文献类型：
--
作者：
Bernstein,IL;Goehler,LE
开发了一种改进的学习食物厌恶范式，模拟了长期接触食物和疾病可能是营养缺乏或肿瘤生长的特征。在这个范例中，持续可用的食物与渗透性小泵提供的缓慢、持续的氯化锂输注有关。在实验I和实验II中，68只大鼠被植入含有氯化锂的小型泵或空泵，并暴露在新的或熟悉的饮食中。在实验III中，由40名SS进行，变量是先前接触相同的饮食。当可获得的饮食是新奇的，而不是熟悉的时候，就会获得显著的厌恶。药物灌输对日常食物摄入量的影响与对厌恶形成的影响是平行的。在使用新饮食的药物治疗的SS患者中，可以看到显著的、持续的食物摄入抑制，但在那些熟悉饮食的患者中，只看到了短暂的下降。通过分离慢性药物注射对食物摄入的直接影响和条件性影响，这些研究提供了强有力的证据，证明习得的食物厌恶会导致厌食症。(参考文献17)(心理信息数据库记录(C)2016 APA，版权所有)
Developed a modified learned food aversion paradigm that simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by an osmotic minipump. In Exps I and II, 68 rats were implanted with minipumps with LiCl or with empty pumps and exposed to novel or familiar diets. In Exp III, conducted with 40 Ss, the variable was prior exposure to the same diet. Significant aversions were acquired when the available diet was novel but not when it was familiar. Effects of drug infusions on daily food intake paralleled those on aversion formation. Marked, persistent suppression of food intake was seen in drug-treated Ss consuming a novel diet, but only transient declines were seen in those with a familiar diet. By separating the direct from the conditioned effects on food intake of chronic drug infusions, these studies provided strong evidence that learned food aversions can lead to anorexia.(17 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)