Photochemical control of biological processes
Photochemical control of biological processes
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DOI：
10.1039/b616410m
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Deiters, Alexander
中科院分区：
文献类型：
--
作者：
Young, Douglas D.;Deiters, Alexander
生物过程的光化学调控提供了一个高水平的控制，以前所未有的空间和时间分辨率研究细胞内的机制。本文综述了近年来紫外光照射在体内调控基因功能方面的研究进展。大多数所描述的应用需要利用安装在生物分子功能的小分子调节剂上或直接安装在生物大分子本身上的光锁定基团。
Photochemical regulation of biological processes offers a high level of control to study intracellular mechanisms with unprecedented spatial and temporal resolution. This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light. The majority of the described applications entail the utilization of photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.