A Ten-Step Total Synthesis of Speradine C
A Ten-Step Total Synthesis of Speradine C
复制标题
Speradine C 的十步全合成
DOI：
10.1002/anie.201902004
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Jia Yanxing
中科院分区：
文献类型：
--
作者：
Liu Haichao;Chen Lijun;Yuan Kuo;Jia Yanxing
从市售的 4-溴吲哚仅用十个步骤就实现了 speradine C 的首次全合成。该工作的显着特点是通过三次环化形成四个环，即生物启发的[3+2]环化形成C/D环，NCS介导的氧化构建E 环，以及Ru催化的酮羟基化组装F 环。这项工作强调了战略环结构如何简化多环化合物的合成。
The first total synthesis of speradine C has been achieved in only ten steps from a commercially available 4‐bromoindole. Salient features of the work are the formation of four rings through three cyclizations, namely a bioinspired [3+2] annulation to form the C/D rings, an NCS‐mediated oxidation to construct the E ring, and a Ru‐catalyzed ketohydroxylation to assemble the F ring. This work highlights how strategic ring constructions can streamline the synthesis of polycyclic compounds.