Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T
Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T
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DOI：
10.1002/mrm.23307
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发表时间：
2012-09-01
影响因子：
3.3
通讯作者：
Regatte, Ravinder R.
中科院分区：
文献类型：
--
作者：
Madelin, Guillaume;Babb, James S.;Regatte, Ravinder R.
骨关节炎是一种关节软骨的退行性疾病，可能与糖胺聚糖的丢失有关。定量钠磁共振成像对糖胺聚糖含量具有高度特异性，可用于评估早期骨关节炎软骨的生化降解。然而，该技术的再现性和可重复性没有很好的记录。本研究的目的是测试体内软骨中钠定量的再现性和可重复性，使用3 T和7 T的日内和日间采集，采用径向3D序列，有和没有液体抑制。通过绝热反转恢复（IR WURST）获得液体抑制，并预期提高该方法对糖胺聚糖含量的灵敏度。变异系数均在7.513.6%之间。没有显着的intermagnet，intersequence，日内和日间差异的变异系数进行了观察。使用IR WURST的钠定量得到的值比径向3D更接近文献中报道的健康软骨（220 - 310 mM）。总之，IR WURST在钠测量方面更准确，其再现性和可重复性与其他软骨成分磁共振成像技术相当。Magn Reson Med，2012年。(c)2011 Wiley Periodicals，Inc.
Osteoarthritis is a degenerative disease of articular cartilage that may be associated with a loss of glycosaminoglycans. Quantitative sodium magnetic resonance imaging is highly specific to glycosaminoglycan content and could be used to assess the biochemical degradation of cartilage in early osteoarthritis. However, the reproducibility and repeatability of this technique are not well documented. The aim of this study is to test the reproducibility and repeatability of sodium quantification in cartilage in vivo using intraday and interday acquisitions at 3 T and 7 T, with a radial 3D sequence, with and without fluid suppression. Fluid suppression was obtained by adiabatic inversion recovery (IR WURST) and is expected to improve the sensitivity of the method to glycosaminoglycan content. The root mean square of coefficients of variation are all in the range of 7.513.6%. No significant intermagnet, intersequence, intraday, and interday differences in the coefficients of variation were observed. Sodium quantification using IR WURST gave values closer to those reported in the literature for healthy cartilage (220310 mM) than radial 3D. In conclusion, IR WURST was more accurate in context of sodium measurement, with a reproducibility and repeatability comparable to other compositional magnetic resonance imaging techniques of cartilage. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.