Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
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DOI：
10.1073/pnas.0910753106
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发表时间：
2009-12-29
影响因子：
11.1
通讯作者：
McClintock, Martha K.
中科院分区：
文献类型：
--
作者：
Hermes, Gretchen L.;Delgado, Bertha;McClintock, Martha K.
In a life span study, we examined how the social environment regulates naturally occurring tumor development and malignancy in genetically prone Sprague-Dawley rats. We randomly assigned this gregarious species to live either alone or in groups of five female rats. Mammary tumor burden among social isolates increased to 84 times that of age-matched controls, as did malignancy, specifically a 3.3 relative risk for ductal carcinoma in situ and invasive ductal carcinoma, the most common early breast cancers in women. Importantly, isolation did not extend ovarian function in late middle age; in fact, isolated animals were exposed to lower levels of estrogen and progesterone in the middle-age period of mammary tumor growth, with unchanged tumor estrogen and progesterone receptor status. Isolates, however, did develop significant dysregulation of corticosterone responses to everyday stressors manifest in young adulthood, months before tumor development, and persisting into old age. Amongisolates, corticosterone response to an acute stressor was enhanced and recovery was markedly delayed, each associated with increased mammary tumor progression. In addition to being stressed and tumor prone, an array of behavioral measures demonstrated that socially isolated females possessed an anxious, fearful, and vigilant phenotype. Our model provides a framework for studying the interaction of social neglect with genetic risk to identify mechanisms whereby psychosocial stressors increase growth and malignancy of breast cancer.
