Alterations in male sexual behaviour, attractiveness and testosterone levels induced by an adult-onset calorie restriction regimen
Alterations in male sexual behaviour, attractiveness and testosterone levels induced by an adult-onset calorie restriction regimen
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DOI：
10.1016/j.bbr.2008.02.013
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发表时间：
2008-06-26
影响因子：
2.7
通讯作者：
Paolini, Antonio G.
中科院分区：
文献类型：
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作者：
Govic, Antonina;Levay, Elizabeth A.;Paolini, Antonio G.
尽管有大量关于热量限制(CR)改变性腺和食欲调节激素的研究，但CR对性行为的影响仍有待系统地研究。本研究比较了雄性成年Wistar大鼠性行为、性伴偏好、血清睾酮和瘦素水平的变化。临时限制(以前的CR)未能改变性行为、伴侣偏好以及睾酮和瘦素水平。中等比例的CR男性没有表现出性行为障碍，但在伴侣偏好的一项衡量标准中，确实显示出对女性的吸引力水平降低。性行为受到显著的CR的影响，因为CR50%的组第一次插入的潜伏期更长，这表明性唤醒发生了变化。与CR50%组相比，女性也始终表现出明显的偏爱对照组。这些发现表明，基本上为CR的动物的总体生殖潜力可能会降低。25%和50%CR组的睾酮水平同样受到抑制，而瘦素水平仅在CR50%组降低。瘦素，而不是睾丸素，可能只影响了基本上完全缓解的动物的性行为损害。然而，睾丸激素可能在调节控制偏好方面发挥作用，而不是CR男性，因为吸引力因大量的CR而完全降低，而通过适度限制的养生法则部分降低。(C)2008爱思唯尔B.V.保留所有权利。
Despite an abundance of research on calorie restriction (CR) altering gonadal and appetite regulating hormones, the sexual behavioural consequences of CR remain to be examined systematically. This study compared the sexual behaviour, partner preference, serum testosterone and leptin levels of male adult Hooded Wistar rats administered a CR (Continuous 25%,50% CR or a temporary restriction) with ad libitum fed controls. The temporary restriction (Previous CR) failed to alter sexual behaviour, partner preference and levels of testosterone and leptin. The moderately 25% CR males did not demonstrate an impairment in sexual behaviour but did demonstrate a reduced level of attractiveness to females in one measure of partner preference. Sexual performance was affected by a substantial CR, as the CR50% group exhibited a longer latency to the first intromission, indicating alteration in sexual arousal. Females also consistently demonstrated a clear preference for the control group compared to the CR50% group. These findings indicate a possible reduction in the overall reproductive potential of the substantially CR animals. Testosterone levels were equally suppressed by both the 25% and 50% CR, while leptin levels were only reduced in the CR50% group. Leptin, rather than testosterone, may have influenced the impairment in sexual behaviour only demonstrated by the substantially CR animals. Testosterone, may, however, play a role in modulating the preference of control over CR males, as attractiveness was totally reduced by a substantial CR, and partially reduced by a moderate restricted regimen. (c) 2008 Elsevier B.V. All rights reserved.