Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone.
Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone.
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DOI：
10.1016/j.arth.2015.08.021
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Steinbeck;Peter Eisenhauer;M. Maltenfort;J. Parvizi;T. Freeman
中科院分区：
文献类型：
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作者：
M. Steinbeck;Peter Eisenhauer;M. Maltenfort;J. Parvizi;T. Freeman
本研究的目的是通过分析软骨下骨来确定骨关节炎病理学的替代机制。股骨髁样本收集自绝经后女性膝关节骨关节炎患者行全膝关节置换术。在大多数患者中，股骨内侧髁区域下的软骨下骨小梁体积加倍，全层软骨退化。然而，在一个患者子集中，该区域的骨体积保持恒定。该亚组在外侧髁的钙化软骨中也有较大面积的血管渗透，同时血管内皮生长因子表达增加。通过软骨下骨特征进行的亚型分型确定了一个独特的人群，该人群缺乏晚期骨关节炎的坐骨特征。骨关节炎人群中亚型的鉴定允许研究替代疾病病理。
The goal of this study was to identify alternative mechanisms of osteoarthritis pathology by analyzing subchondral bone. Femoral condyle samples were collected from post-menopausal female patients with knee osteoarthritis undegoing total knee arthroplasty. In the majority of patients, subchondral trabecular bone volume doubled under a region of the medial femoral condyle with full-thickness cartilage deterioration. However, in a subset of patients the bone volume in this region remained constant. This subset also had larger areas of vascular penetration in the calcified cartilage of the lateral condyle concurrent with increased vascular endothelial growth factor expression. Subtyping by subchondral bone characteristics identified a unique population, which lacked the sclerotic bone characteristic of late-stage osteoarthritis. Identification of subtypes within the osteoarthritis population allows investigation of alternate disease pathologies.