Involvement of EBV-encoded BART-miRNAs and dysregulated cellular miRNAs in nasopharyngeal carcinoma genesis.
Involvement of EBV-encoded BART-miRNAs and dysregulated cellular miRNAs in nasopharyngeal carcinoma genesis.
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DOI：
10.7314/apjcp.2013.14.10.5637
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发表时间：
2013-10
期刊：
影响因子：
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通讯作者：
Yuanjie Xie;Z. Long;Xiu-sheng He
中科院分区：
文献类型：
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作者：
Yuanjie Xie;Z. Long;Xiu-sheng He
鼻咽癌（NPCs）发生的确切分子机制仍有待完全阐明。mirna是一种小的非编码rna，通过转录后负调控基因表达参与细胞增殖、凋亡甚至致癌。EBV是第一个被发现表达mirna的人类病毒。ebv编码的bart - mirna和失调的细胞mirna通过干扰与免疫应答相关的病毒和宿主细胞基因的表达，干扰增殖、凋亡、侵袭、转移甚至放化疗敏感性的信号通路，参与鼻咽癌的癌变。进一步研究ebv编码的mirna和细胞mirna的作用，将为了解复杂的基因调控网络提供新的见解，并为鼻咽癌的诊断、治疗和预后提供新的策略。
The definite molecular mechanisms underlying the genesis of nasopharyngeal carcinomas (NPCs) remain to be completely elucidated. miRNAs are small non-coding RNAs which are implicated in cell proliferation, apoptosis, and even carcinogenesis through negatively regulating gene expression post-transcriptionally. EBV was the first human virus found to express miRNAs. EBV-encoded BART-miRNAs and dysregulated cellular miRNAs are involved in carcinogenesis of NPC by interfering in the expression of viral and host cell genes related to immune responses and perturbing signal pathways of proliferation, apoptosis, invasion, metastasis and even radio-chemo-therapy sensitivity. Additional studies on the roles of EBV-encoded miRNAs and cellular miRNAs will provide new insights concerning the complicated gene regulated network and shed light on novel strategies for the diagnosis, therapy and prognosis of NPC.