Intrinsic and extrinsic factors regulating vertebrate neurogenesis
Intrinsic and extrinsic factors regulating vertebrate neurogenesis
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DOI：
10.1016/0959-4388(95)80082-4
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发表时间：
1995-01-01
影响因子：
5.7
通讯作者：
Calof, Anne L.
中科院分区：
文献类型：
--
作者：
Calof, Anne L.
最近的脊椎动物神经发生调控因子的研究揭示了三个新的主题。首先，这个过程中涉及的细胞阶段的数量可能比以前认识到的要多。第二，调节无脊椎动物神经发生的基因的同源物似乎在脊椎动物神经系统的发育中发挥类似的作用。第三，外在因素可以通过控制神经祖细胞的存活和分化而不仅仅是增殖来调节神经发生期间的神经元数量。
Recent studies of the factors regulating neurogenesis in vertebrates reveal three emerging themes. First, the number of cellular stages involved in this process may be greater than has previously been appreciated. Second, homologues of genes that regulate neurogenesis in invertebrates appear to play analogous roles in development of vertebrate nervous systems. Third, extrinsic factors can act to regulate neuron number during neurogenesis by controlling survival and differentiation, and not simply proliferation, of neural progenitor cells.