The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: Linking gastric and Alzheimer's diseases together?
The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: Linking gastric and Alzheimer's diseases together?
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DOI：
10.1016/j.mehy.2011.07.038
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发表时间：
2011-11-01
影响因子：
4.7
通讯作者：
Sun, Xuesong
中科院分区：
文献类型：
--
作者：
Ge, Ruiguang;Sun, Xuesong
幽门螺杆菌可引起胃炎、消化性溃疡、胃癌和MALT淋巴瘤等胃病。Hpn是一种富含组氨酸的蛋白质，在这种细菌中大量存在，并在生理相关条件下形成淀粉样低聚物。在这里，我们提出了这种蛋白质的体内功能与其物理位置的相关性。本文提供的证据有助于阐明H.幽门螺杆菌感染，重点是在胃环境中的细菌定植，对胃上皮细胞的病理影响和与阿尔茨海默病的可能联系。(C)2011爱思唯尔有限公司保留所有权利。
Helicobacter pylori causes such gastric diseases as gastritis, peptic ulcerations, gastric cancer and MALT lymphoma. Hpn is a histidine-rich protein abundant in this bacterium and forms amyloid-like oligomers in physiologically relevant conditions. Here we proposed the in vivo functions of this protein with relevance to its physical locations. The collective evidence presented here shed some light on the pathologic mechanisms of H. pylori infections, with emphasis on the bacterial colonization in the gastric environment, pathological effects to the gastric epithelial cells and the possible link to Alzheimer's disease. (C) 2011 Elsevier Ltd. All rights reserved.