Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study
Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study
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DOI：
10.3945/ajcn.112.039990
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发表时间：
2012-12-01
影响因子：
7.1
通讯作者：
Mozaffarian, Dariush
中科院分区：
文献类型：
--
作者：
Imamura, Fumiaki;Lemaitre, Rozenn N.;Mozaffarian, Dariush
背景资料：饮食和代谢的复杂相互作用影响循环脂肪酸（FA），可能构成与心血管疾病（CVD）风险相关的FA模式。目的：我们的目的是从循环FA中推导出FA模式，将模式与CVD发病率相关，并将推导出的模式扩展到另一个独立队列的动脉粥样硬化进展。设计：我们使用主成分分析（PCA）从心血管健康研究（CHS）中的2972名老年人的38种血浆磷脂FA中获得FA模式。对所识别的模式与14年CVD [缺血性心脏病（IHD）或卒中]发病率的前瞻性关联进行了评估。在另一个独立的队列绝经后妇女IHD，我们评估协会的CHS衍生的模式与3.2年的进展血管造影定义的冠状动脉atherosclerosis.Results：三种不同的模式被确定，其特点是较高比例的反式脂肪酸，从头脂肪生成（DNL）脂肪酸，和长链MUFAs（LCMUFAs）。在32，265人-年期间，发生了780起CVD事件。反式FA模式与较高的CVD风险相关（最高与最低五分位数的多变量校正HR = 1.58; 95% CI：1.17，2.12; P趋势= 0.006），主要归因于较高的卒中风险（HR：2.46; 95% CI：1.54，3.92; P趋势= 0.005）。DNL和LCMUFA模式与CVD发病率或IHD或卒中无关（P趋势均> 0.11）。在第二个队列中，反式FA模式，而不是其他两种模式，与冠状动脉粥样硬化的进展呈正相关（P趋势< 0.05）。结论：PCA似乎提供了信息的循环FA模式。一种主要由反式FA水平驱动的模式，与老年人更高的CVD风险和IHD女性冠状动脉粥样硬化进展相关。美国临床营养杂志2012;96：1252-61。
Background: Complex interplays of diet and metabolism influence circulating fatty acids (FAs), possibly constituting FA patterns related to cardiovascular disease (CVD) risk.Objectives: We aimed to derive FA patterns from circulating FAs, relate the patterns to CVD incidence, and extend the derived patterns to atherosclerosis progression in another independent cohort.Design: We used principal component analysis (PCA) to derive FA patterns from 38 plasma phospholipid FAs in 2972 older adults in the Cardiovascular Health Study (CHS). Identified patterns were evaluated for prospective associations with 14-y incidence of CVD [ischemic heart disease (IHD) or stroke]. In another independent cohort of postmenopausal women with IHD, we evaluated associations of the CHS-derived patterns with 3.2-y progression of angiographically defined coronary atherosclerosis.Results: Three distinct patterns were identified, characterized by higher proportions of trans FAs, de novo lipogenesis (DNL) FAs, and long-chain MUFAs (LCMUFAs). During 32,265 person-years, 780 incident CVD events occurred. The trans FA pattern was associated with higher CVD risk (multivariable-adjusted HR for the highest compared with the lowest quintiles = 1.58; 95% CI: 1.17, 2.12; p-trend = 0.006), primarily attributable to higher risk of stroke (HR: 2.46; 95% CI: 1.54, 3.92; P-trend = 0.005). The DNL and LCMUFA patterns were not associated with CVD incidence or with IHD or stroke (P-trend > 0.11 each). In the second cohort, the trans FA pattern, but not the other 2 patterns, was positively associated with progression of coronary atherosclerosis (P-trend < 0.05).Conclusions: PCA appears to provide informative circulating FA patterns. A pattern driven mainly by trans FA levels related to greater CVD risk in older adults and coronary atherosclerosis progression in women with IHD. Am J Clin Nutr 2012;96:1252-61.