Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function.
Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function.
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DOI：
10.1155/2011/676208
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发表时间：
2011
影响因子：
2.2
通讯作者：
Yoshikawa T
中科院分区：
文献类型：
--
作者：
Aoi W;Naito Y;Yoshikawa T
久坐不动的生活方式会导致代谢综合征的发展。代谢综合征与骨骼肌的代谢功能有关，骨骼肌是营养素的主要消耗者。饮食运动，沿着充足的饮食，据报道是代谢综合征的主要预防疗法之一;运动提高肌肉的代谢能力并防止肌肉质量的损失。流行病学研究表明，体育活动可以降低各种常见疾病的风险，如心血管疾病，糖尿病和癌症;它还有助于减少内脏脂肪组织。此外，实验室研究已经证明了单次和定期锻炼的益处的机制。运动调节肌肉中与代谢和合成代谢信号相关的蛋白质的表达/活性，导致表型的变化。这些变化的程度取决于运动的强度、持续时间和频率。运动的效果也部分归因于炎症的减少，炎症已被证明与各种疾病的发展密切相关。此外，有人认为天然食物中含有的几种植物化学物质可以改善营养代谢，防止肌肉中的蛋白质降解。
A sedentary lifestyle can cause metabolic syndrome to develop. Metabolic syndrome is associated with metabolic function in the skeletal muscle, a major consumer of nutrients. Dietary exercise, along with an adequate diet, is reported to be one of the major preventive therapies for metabolic syndrome; exercise improves the metabolic capacity of muscles and prevents the loss of muscle mass. Epidemiological studies have shown that physical activity reduces the risk of various common diseases such as cardiovascular disease, diabetes, and cancer; it also helps in reducing visceral adipose tissue. In addition, laboratory studies have demonstrated the mechanisms underlying the benefits of single-bout and regular exercise. Exercise regulates the expression/activity of proteins associated with metabolic and anabolic signaling in muscle, leading to a change in phenotype. The extent of these changes depends on the intensity, the duration, and the frequency of the exercise. The effect of exercise is also partly due to a decrease in inflammation, which has been shown to be closely related to the development of various diseases. Furthermore, it has been suggested that several phytochemicals contained in natural foods can improve nutrient metabolism and prevent protein degradation in the muscle.