AMPHIDINOLIDE-C - THE 1ST 25-MEMBERED MACROCYCLIC LACTONE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP
AMPHIDINOLIDE-C - THE 1ST 25-MEMBERED MACROCYCLIC LACTONE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP
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DOI：
10.1021/ja00210a029
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发表时间：
1988-01-20
影响因子：
15
通讯作者：
OHIZUMI, Y
中科院分区：
文献类型：
--
作者：
KOBAYASHI, J;ISHIBASHI, M;OHIZUMI, Y
实验室培养甲藻前沟藻Amphidinium sp.浸提液的研究与冲绳扁形虫Amphiscolops sp.共生，已导致在分离的amphidinocyte C，第一个25元大环内酯具有强大的抗肿瘤活性。主要根据波谱数据，特别是几种类型的二维NMR谱，包括1H-检测的杂原子多键相关法，对其结构进行了鉴定。
Investigation on the extract of the laboratory cultured dinoflagellate Amphidinium sp., which was symbiotically associated with an Okinawan flatworm Amphiscolops sp., has resulted in the isolation of amphidinolide C, the first 25-membered macrocyclic lactone with potent antineoplastic activity. The structure has been elucidated mainly on the basis of spectroscopic data, especially several types of two-dimensional NMR spectra including 1H-detected heteronuclear multiple-bond correlation method.