Incidence of lung cancer in a large cohort of non-smoking men from Sweden
Incidence of lung cancer in a large cohort of non-smoking men from Sweden
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DOI：
10.1002/ijc.1507
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发表时间：
2001-11-15
影响因子：
6.4
通讯作者：
Nyrén, O
中科院分区：
文献类型：
--
作者：
Boffetta, P;Järvholm, B;Nyrén, O
关于非吸烟者肺癌发生率的有效数据很少，主要是指北美人群。我们研究的目的是提供一个估计的发病率在非吸烟者在一个大的欧洲人口。从瑞典建筑工人的全国性保健计划出发，我们估计了1971- 1992年期间在一次或多次体检（平均2.9次）中报告从不吸烟的143，998名男性的肺癌发病率。1971- 1995年的癌症发病率数据是通过与几乎完整的国家癌症登记处联系获得的。队列成员贡献了超过200万人年的观察，在此期间发生了101例肺癌。年龄标准化率为3.7/100，000（95%置信区间[CI] 2.8-4.6）。有迹象表明存在日历周期效应，失业率从1976-80年的1.5/100，000增加到1991-95年的5.4/100，000。还提出了出生队列效应。该人群的估计发生率与北美研究的发生率相当。研究期间的增长率可能是由于非吸烟者养成了这种习惯，但它也可能反映了非吸烟者肺癌其他危险因素影响的时间变化。(C)2001 Wiley-Liss，Inc.
Valid data on the occurrence of lung cancer among nonsmokers are sparse and refer mainly to North American populations. The objective of our study is to provide an estimate of the incidence of lung cancer among non-smokers in a large European population. Proceeding from a nationwide health care program among Swedish construction workers, we estimated the incidence of lung cancer among 143,998 males who reported to be never smokers at I or several physical check-ups (average, 2.9 visits) during 1971-92. Cancer incidence data for 1971-95 were obtained through linkage with the virtually complete national cancer registry. Cohort members contributed over 2 million person-years of observation, during which 101 lung cancers occurred. The age-standardized rate was 3.7/100,000 (95% confidence interval [CI] 2.8-4.6). There was a suggestion of a calendar period effect, with rates increasing from 1.5/100,000 in 1976-80 to 5.4/100,000 in 1991-95. A birth cohort effect was also suggested. Rates estimated in this population are comparable to those from North American studies. The increasing rate during the study period might be due to non-smokers who took up the habit, but it might also reflect temporal changes in the effect of other risk factors of lung cancer in non-smokers. (C) 2001 Wiley-Liss, Inc.