A kinase for light and time.
A kinase for light and time.
复制标题
光和时间的激酶。
DOI：
10.1111/j.1365-2958.2005.04546.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Loros,Jennifer
中科院分区：
文献类型：
--
作者：
Loros,Jennifer
真核丝状真菌粗糙脉孢菌已被证明是分析光调控基因表达和昼夜节律的可靠模型系统。核心生物钟的分子基础是一个基于转录/翻译的反馈环，其中白色-collar 1（WC-1）和白色-collar 2（WC-2）蛋白的异二聚体作为转录因子，促进时钟、frqmRNA和FRQ蛋白中负元件的表达。此外，WC-1是一种黄素蛋白，作为环境光的主要反应者，与WC-2一起，是生物钟和其他光调节过程的主要感光体。蛋白激酶C作为WC-1蛋白的光依赖性调节剂。
The eukaryotic filamentous fungusNeurospora crassahas proven to be a dependable model system for the analysis of light‐regulated gene expression and circadian rhythmicity. The molecular basis of the core circadian clock is a transcription/translation‐based feedback loop in which a heterodimer of the white‐collar 1 (WC‐1) and white‐collar 2 (WC‐2) proteins act as a transcription factor to promote expression of the negative elements in the clock,frqmRNA and FRQ protein. Additionally, WC‐1 is a flavoprotein that acts as the primary responder to environmental light and, in conjunction with WC‐2, is the major photoreceptor for the clock as well as other light‐regulated processes. Protein kinase C acts as a light‐dependent regulator of the WC‐1 protein.