Transcranial Direct-Current Stimulation Can Enhance Motor Learning in Children
Transcranial Direct-Current Stimulation Can Enhance Motor Learning in Children
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DOI：
10.1093/cercor/bhw114
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发表时间：
2017-05-01
期刊：
影响因子：
3.7
通讯作者：
Kirton, Adam
中科院分区：
文献类型：
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作者：
Ciechanski, Patrick;Kirton, Adam
本研究旨在确定经颅直流电刺激 (tDCS) 对健康学龄儿童运动学习的影响。还探讨了安全性、耐受性以及对未经训练任务的影响的转化。我们招募了 24 名惯用右手的儿童进行一项随机、假对照、双盲试验，在连续 3 天的运动任务练习中接受：右侧初级运动皮层 (M1) 1 mA 阳极 (1A-tDCS)、左侧 M1 1 mA 阴极 (1C-tDCS)、左侧 M1 2 mA 阴极 tDCS (2C-tDCS) 或假 tDCS。参与者在 tDCS 应用期间训练他们的左手执行普渡大学钉板测试 (PPT)。在基线和训练后测试了右手和双手 PPT、捷成泰勒测试 (JTT) 和串行反应时间任务 (SRTT)。六周后重新测试所有措施。与假手术相比，主动 tDCS 蒙太奇增强了运动学习（所有 P < 0.002）。效果持续 6 周。蒙太奇之间的效果大小很大并且具有可比性：对侧 1A-tDCS（Cohen's d = 2.58）和同侧 1C-tDCS（3.44）和 2C-tDCS（2.76）。通过 tDCS，未经训练的手动 PPT、双边 JTT 和 SRTT 的表现通常会得到改善。 tDCS 耐受性良好且安全，没有出现不良事件。这些首要原则将促进 tDCS 与治疗的结合，以增强脑瘫儿童等残疾儿童的康复。
This study aims to determine the effects of transcranial direct-current stimulation (tDCS) on motor learning in healthy school-aged children. Safety, tolerability, and translation of effects to untrained tasks were also explored. We recruited 24 right-handed children for a randomized, sham-controlled, double-blinded trial to receive: right primary motor cortex (M1) 1 mA anodal (1A-tDCS), left M1 1 mA cathodal (1C-tDCS), left M1 2 mA cathodal tDCS (2C-tDCS), or sham tDCS over 3 consecutive days of motor task practice. Participants trained their left hand to perform the Purdue Pegboard Test (PPT) during tDCS application. Right hand and bimanual PPT, the Jebsen-Taylor Test (JTT), and the Serial Reaction Time Task (SRTT) were tested at baseline and post-training. All measures were retested 6 weeks later. Active tDCS montages enhanced motor learning compared with sham (all P < 0.002). Effects were sustained at 6 weeks. Effect sizes were large and comparable across montages: contralateral 1A-tDCS (Cohen's d = 2.58) and ipsilateral 1C-tDCS (3.44) and 2C-tDCS (2.76). Performance in the untrained hand PPT, bilateral JTT, and SRTT often improved with tDCS. tDCS was well-tolerated and safe with no adverse events. These first principles will advance the pairing of tDCS with therapy to enhance rehabilitation for disabled children such as those with cerebral palsy.