THE EFFECT OF INSECTICIDE-TREATED BED NETS ON MORTALITY OF GAMBIAN CHILDREN
THE EFFECT OF INSECTICIDE-TREATED BED NETS ON MORTALITY OF GAMBIAN CHILDREN
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DOI：
10.1016/0140-6736(91)93194-e
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发表时间：
1991-06-22
期刊：
影响因子：
168.9
通讯作者：
GREENWOOD, BM
中科院分区：
文献类型：
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作者：
ALONSO, PL;LINDSAY, SW;GREENWOOD, BM
对蚊帐（“蚊帐”）进行无害化处理可能是降低疟疾引起的发病率和死亡率的一种廉价和可接受的方法。在冈比亚的一个农村地区，在疟疾传播季节开始时，参加初级保健计划的村庄的蚊帐用氯菊酯处理。此外，6个月至5岁的儿童在整个疟疾传播季节随机接受每周一次的Maloprim或安慰剂的化学预防。我们测量了所述干预措施之前和之后原发性肝癌村庄儿童的死亡率，并将其与未采取干预措施的村庄（非原发性肝癌村庄）的死亡率进行比较。原发性肝癌村庄约92%的儿童睡在经过杀虫剂处理的蚊帐下。在干预前一年，非初级保健村庄1-4岁儿童的死亡率较低。干预后，干预村1-4岁儿童的总死亡率和疟疾死亡率分别为非PHC村的37%和30%。在睡在驱虫蚊帐下的儿童中，我们没有发现任何证据表明化学预防在预防死亡方面有额外的好处。经杀虫剂处理的蚊帐易于引进，可降低疟疾死亡率。
Insecticide treatment of bed nets ("mosquito nets") may be a cheap and acceptable method of reducing the morbidity and mortality caused by malaria. In a rural area of The Gambia, bed nets in villages participating in a primary health-care (PHC) scheme were treated with permethrin at the beginning of the malaria transmission season. Additionally, children aged 6 months to 5 years were randomised to receive weekly either chemoprophylaxis with maloprim or a placebo throughout the malaria transmission season. We measured mortality in children in PHC villages before and after the interventions described, and compared this with mortality in villages where no interventions occurred (non-PHC villages).About 92% of children in PHC villages slept under insecticide-treated bed nets. In the year before intervention, mortality in children aged 1-4 years was lower in non-PHC villages. After intervention, the overall mortality and mortality attributable to malaria of children aged 1-4 in the intervention villages was 37% and 30%, respectively, of that in the non-PHC villages. Among children who slept under treated nets, we found no evidence of an additional benefit of chemoprophylaxis in preventing deaths. Insecticide-treated bed nets are simple to introduce and can reduce mortality from malaria.