High resolution MR perfusion imaging of the kidneys at 3 Tesla without administration of contrast media
High resolution MR perfusion imaging of the kidneys at 3 Tesla without administration of contrast media
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DOI：
10.1055/s-2005-858761
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发表时间：
2005-12-01
影响因子：
1.8
通讯作者：
Schick, F
中科院分区：
文献类型：
--
作者：
Boss, A;Martirosian, P;Schick, F
目的：在3特斯拉条件下，使用流量敏感交替反转恢复（FAIR）稳态进动真快速成像（TrueFISP）技术，对肾脏高分辨率动脉自旋标记（ASL）灌注成像的可行性进行了测试和证明。材料和方法：使用临床3特斯拉全身扫描仪获得6名健康志愿者和2名患者的肾脏灌注图。采用FAIR自旋准备和TrueFISP信号检测策略的ASL序列适用于3特斯拉下肾脏的高分辨率灌注成像。为了避免TrueFISP图像中的条带伪影（通常在3特斯拉时突出），实施了频率侦察。以横向和冠状方向记录面内分辨率为1.5 mm的灌注图。对于全肾灌注的快速标测，采用2 mm的平面内分辨率。结果如下：在所有志愿者和患者中，能够在大约10分钟的测量时间内获得具有优异图像质量的高分辨率灌注图像。整个肾脏能够在不到10分钟的时间内以良好的图像质量进行映射。对于所有切片，适当的频率偏移使得能够在没有TrueFISP伪影的情况下再现肾脏。肾皮质灌注值范围为250 ml/100 g/min至400 ml/100 g/min（右肾平均皮质灌注316 43，左肾336 40）。结论：在临床适用的测量时间内，通过3 T MR设置，能够获得整个肾脏的高分辨率ASL灌注图像，图像质量良好，从而为涉及潜在肾毒性造影剂的常规灌注成像提供了替代方案。
Purpose: The feasibility of high-resolution arterial spin labeling (ASL) perfusion imaging of the kidneys was tested and proven at 3 Tesla using a flow-sensitive alternating inversion recovery (FAIR) true fast imaging in steady precession (TrueFISP) technique. Materials and Methods: Kidney perfusion maps of six healthy volunteers and two patients were acquired using a clinical 3-Tesla whole-body scanner. An ASL sequence with FAIR spin preparation and a TrueFISP signal detection strategy was adapted for high-resolution perfusion imaging of the kidneys at 3 Tesla. To avoid banding artifacts in TrueFISP images, which are generally prominent at 3 Tesla, a frequency scout was implemented. Perfusion maps with an in-plane resolution of 1.5 mm were recorded in transverse and coronal orientation. For fast mapping of whole-kidney perfusion, an in-plane resolution of 2 mm was applied. Results: In all volunteers and patients, high-resolution perfusion images with excellent image quality were able to be obtained in a measuring time of approximately 10 minutes. The whole kidney was able to be mapped with good image quality in less than 10 minutes. For all slices, a suitable frequency offset made it possible to reproduce the kidneys without TrueFISP artifacts. Perfusion values of the renal cortex ranged from 250 ml/100 g/min up to 400 ml/100 g/min (mean cortical perfusion right kidney 316 43, left 336 40). Conclusion: High-resolution ASL perfusion images of the whole kidney were able to be obtained with good image quality by means of a 3 Tesla MR setting within a clinically applicable measuring time, thus providing an alternative to conventional perfusion imaging involving potentially nephrotoxic contrast media.