Evaluation of Hepatitis C Virus Core Antigen Assays in Detecting Recombinant Viral Antigens of Various Genotypes
Evaluation of Hepatitis C Virus Core Antigen Assays in Detecting Recombinant Viral Antigens of Various Genotypes
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DOI：
10.1128/jcm.01437-09
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发表时间：
2009-12-01
影响因子：
9.4
通讯作者：
Suzuki, Tetsuro
中科院分区：
文献类型：
--
作者：
Saeed, Mohsan;Suzuki, Ryosuke;Suzuki, Tetsuro
丙型肝炎病毒核心抗原序列A48T中的一个单一取代，在30%的基因型2a病毒感染者中观察到，降低了常用的化学发光酶免疫测定法的灵敏度。通过使用具有不同表位的不同抗核心抗体来改善抗原的定量。
A single substitution within the hepatitis C virus core antigen sequence, A48T, which is observed in similar to 30% of individuals infected with genotype 2a virus, reduces the sensitivity of a commonly used chemiluminescence enzyme immunoassay. Quantitation of the antigen is improved by using a distinct anticore antibody with a different epitope.