IMPAIRED EXTRA-DIMENSIONAL SHIFT PERFORMANCE IN MEDICATED AND UNMEDICATED PARKINSONS-DISEASE - EVIDENCE FOR A SPECIFIC ATTENTIONAL DYSFUNCTION
IMPAIRED EXTRA-DIMENSIONAL SHIFT PERFORMANCE IN MEDICATED AND UNMEDICATED PARKINSONS-DISEASE - EVIDENCE FOR A SPECIFIC ATTENTIONAL DYSFUNCTION
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DOI：
10.1016/0028-3932(89)90128-0
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发表时间：
1989-01-01
期刊：
影响因子：
2.6
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
DOWNES, JJ;ROBERTS, AC;ROBBINS, TW
帕金森病患者组（无论是接受药物治疗还是未接受药物治疗）以及处于病程早期的患者，以及年龄和智商匹配的对照受试者，都在两种范式中进行了测试，以测量选择性注意力的不同方面。第一组测试比较了维度内和维度外转变后的视觉辨别学习，使用“总体改变”设计，其中每次转变都是在用作辨别的复合刺激的新范例存在的情况下进行的。第二个测试包括视觉搜索任务，其中备选方案的数量各不相同。第一个实验的结果显示，两组帕金森病受试者执行超维度转变的能力均存在选择性缺陷。在这项视觉搜索任务中，患者的准确度较低，但其选择反应时间与对照组相当。研究结果根据帕金森病中发生的注意力功能障碍的性质进行了讨论。
Groups of patients with Parkinson''s disease, either medicated, or unmedicated and early in the course, together with age- and IQ-matched control subjects were tested in two paradigms measuring different aspects of selective attention. The first set of tests compared visual discrimination learning following intra- and extra-dimensional shifts, using a "total change" design in which each shift was made in the presence of novel exemplars of the compound stimuli used as discriminanda. The second test consisted of a visual search task in which the number of alternatives was varied. The results of the first experiment showed a selective deficit in both groups of Parkinsonian subjects in their ability to perform an extra-dimensional shift. In this visual search task, the patients were less accurate, but responded with equivalent choice reaction times to those of controls. The results are discussed in terms of the nature of the attentional dysfunction that occurs in Parkinson''s disease.