NICOTINE INTAKE AND DEPENDENCE IN SWEDISH SNUFF TAKERS
NICOTINE INTAKE AND DEPENDENCE IN SWEDISH SNUFF TAKERS
复制标题
DOI：
10.1007/bf02247429
复制
发表时间：
1992-09-01
影响因子：
3.4
通讯作者：
FEYERABEND, C
中科院分区：
文献类型：
--
作者：
HOLM, H;JARVIS, MJ;FEYERABEND, C
报告了两项研究瑞典湿鼻烟使用者的尼古丁摄入量。十名使用者在隔夜禁欲后一撮（2 g）的吸收相当迅速。血浆尼古丁浓度平均增加9.9 ng/ml 10 min后（SD 6.5），峰值为14.5 ng/ml（SD 4.6）丢弃后不久在30分钟。在习惯性鼻烟吸食者（n = 27）和吸烟者（n = 3 5）在正常鼻烟/吸烟一天的研究组，使用后的峰值血液尼古丁水平相似[平均36.6 ng/ml（SD 14.4）和36.7 ng/ml（SD 16. 1），分别]，但有较高的可替宁水平在鼻烟（399.2 ng/ml对306.3 ng/ml）的趋势。鼻烟吸食者和吸烟者报告了对烟草的主观依赖程度相似。对瑞典鼻烟使用者的流行病学研究可以澄清烟草的心血管风险是否归因于尼古丁或其他烟雾成分，因为在他们的情况下，尼古丁摄入并不伴随燃烧产物。
Two studies examining nicotine intake in users of Swedish moist oral snuff are reported. Absorption form a single pinch (2 g) in ten users after overnight abstinence was fairly rapid. The increment in plasma nicotine concentrations averaged 9.9 ng/ml (SD 6.5) after 10 min and peaked at 14.5 ng/ml (SD 4.6) shortly after discarding at 30 min. Among groups of habitual snuff takers (n = 27) and cigarette smokers (n = 3 5) studied on a day of normal snuffing/smoking, peak blood nicotine levels after use were similar [averaging 36.6 ng/ml (SD 14.4) and 36.7 ng/ml (SD 16. 1), respectively], but there was a tendency to higher cotinine levels in the snuffers (399.2 ng/ml versus 306.3 ng/ml). The snuff takers and cigarette smokers reported similar levels of subjective dependence on tobacco. Epidemiological study of Swedish snuff users could clarify whether the cardiovascular risks of tobacco are attributable to nicotine or to other smoke components, as in their case nicotine intake is not accompanied by combustion products.