RESPIRATORY-RELATED DISCHARGE PATTERN OF SYMPATHETIC-NERVE ACTIVITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT
RESPIRATORY-RELATED DISCHARGE PATTERN OF SYMPATHETIC-NERVE ACTIVITY IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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DOI：
10.1113/jphysiol.1990.sp018142
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发表时间：
1990-07-01
影响因子：
5.5
通讯作者：
TRZEBSKI, A
中科院分区：
文献类型：
--
作者：
CZYZYKKRZESKA, MF;TRZEBSKI, A
在切断迷走神经、血压正常的Wistar-Kyoto大鼠（WKYs）和年龄匹配的自发性高血压大鼠（SHR）的颈神经和肾神经中研究了呼吸周期中交感神经自发放电的同步性。膈神经放电被用作中枢吸气活动的指标。2.在血压正常的Wistar-Kyoto大鼠中，交感神经活动的抑制出现在吸气开始时，在吸气中期达到最低点。峰值最大交感神经放电对应于吸气后阶段，第二次增加，有时出现在呼气后期。呼吸频率的变化在宽范围的实验条件下，缺氧，高氧，高或低碳酸和横断颈动脉窦神经没有影响这种模式。3.在自发性高血压大鼠的交感神经放电的交感神经相位相关的时间是可变的。在常氧下，最大的交感神经活动发生在吸气后期，之前是吸气早期的短暂抑郁，然后是吸气后抑郁。在呼气中期观察到交感神经活动的第二次增加。4.缺氧刺激外周化学感受器改变了自发性高血压大鼠呼吸相位调制交感神经活动的模式。吸气早期抑制交感神经活动的时间明显延长，最大交感神经放电由吸气提前到呼气早期。切断颈动脉窦神经后，这种效应消失。5.高碳酸刺激的中央化学感受器在SHR与颈动脉窦神经切断不影响的交感神经活动的呼吸相的时间，虽然节律性交感神经放电的幅度增加。6.我们讨论了中枢呼吸驱动和交感神经系统之间的同步性改变可能有助于自发性高血压的神经机制。
Synchronization of spontaneous sympathetic discharge during the respiratory cycle was studied in the cervical and renal nerves of vagotomized, normotensive Wistar-Kyoto rats (WKYs) and age-matched spontaneously hypertensive rats (SHRs). Phrenic nerve discharge was used as an index of central inspiratory activity. 2. In normotensive Wistar-Kyoto rats depression of sympathetic activity appeared at the onset of inspiration reaching a minimum at mid-inspiration. Peak maximal sympathetic discharge corresponded to postinspiratory phase; a second increase sometimes appeared in late expiration. Variations of respiratory frequency over wide range of experimental conditions by hypoxia, hyperoxia, hyper- or hypocapnia and transection of carotid sinus nerves did not affect this pattern. 3. In SHRs the respiratory-phase-related timing of sympathetic discharge was variable. In normoxia, the maximal sympathetic activity occurred in late inspiration, preceded by short depression at early inspiration and followed by postinspiratory depression. A second increase in sympathetic activity was observed in mid-expiration. 4. The pattern of respiratory phase modulated sympathetic activity in SHRs was altered by hypoxic stimulation of the peripheral chemoreceptors. The early inspiratory depression of sympathetic activity was substantially prolonged and the maximal sympathetic discharge was shifted from inspiration to early expiration. This effect was abolished after carotid sinus nerves had been cut. 5. Hypercapnic stimulation of central chemoreceptors in SHRs with carotid sinus nerves cut did not influence the timing of the sympathetic activity in relation to the respiratory phase, though the magnitude of rhythmical sympathetic discharges was increased. 6. We discuss the possibility that altered synchronization between central respiratory drive and sympathetic neuronal system may contribute to the neurogenic mechanisms of arterial hypertension in SHRs.