Anxiety, motor activation, and maternal-infant interactions in 5HT1B knockout mice.
Anxiety, motor activation, and maternal-infant interactions in 5HT1B knockout mice.
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DOI：
10.1037//0735-7044.113.3.587
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发表时间：
1999-06
影响因子：
1.9
通讯作者：
D. Brunner;M. Buhot;R. Hen;M. Hofer
中科院分区：
文献类型：
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作者：
D. Brunner;M. Buhot;R. Hen;M. Hofer
这项研究描述了缺乏5-羟色胺(5-羟色胺)1B受体的小鼠和野生型对照小鼠焦虑和运动激活的发展，并描述了它们早期的母婴互动。在隔离诱导的超声波发声范式中，5HT1b基因敲除幼崽比野生型幼崽发声少，多动，直立，跳跃和打滚。产后一周，5HT1b基因敲除的母亲在巢外的时间比野生型母亲多20%，而且多动症、养育和爬到笼子边缘的次数也比野生型母亲多。幼仔取回不存在基因效应。被击倒的成年人在高架的正迷宫中焦虑较少，排便较少，低头较多，尽管焦虑的标准衡量标准(时间和张开双臂的条目)都没有不同。5HT1b基因敲除小鼠在24小时周期的明暗两个阶段都表现出高度活跃。因此，5HT1b基因敲除小鼠表现出较少的焦虑，并且在他们的一生中都是过度活跃的。
This study describes the development of anxiety and motor activation in mice lacking the serotonin (5HT) 1B receptor and in wild type controls and characterizes their early mother-infant interactions. In the isolation-induced ultrasonic vocalization paradigm, 5HT1B knockout pups vocalized less and were hyperactive, rearing, jumping, and rolling more often than wild type pups. One week postpartum, 5HT1B knockout mothers spent 20% more of their time outside the nest and were also hyperactive, rearing and climbing to the edge of the cage more often than the wild type mothers. There were no genotype effects on pup retrieval. Knockout adults were less anxious in the elevated plus-maze, defecated less, and head-dipped more, although none of the standard measures of anxiety (time and entries in the open arms) were different. 5HT1B knockout mice of both sexes were hyperactive during both the light and the dark phases of the 24-hr cycle. Thus, 5HT1B knockout mice show reduced anxiety and are hyperactive throughout their life.