Treatment of advanced malignant eccrine poroma with locoregional chemotherapy
Treatment of advanced malignant eccrine poroma with locoregional chemotherapy
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DOI：
10.1111/j.1365-2133.2005.06472.x
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发表时间：
2005-05-01
影响因子：
10.3
通讯作者：
Tsiftsis, DD
中科院分区：
文献类型：
--
作者：
de Bree, E;Volalakis, E;Tsiftsis, DD
摘要恶性小汗腺汗孔瘤是一种罕见的疾病，文献上约有200例报告。区域皮肤和全身转移很少观察到，他们的管理一般是不成功的。我们报告的情况下，局部应用5-氟尿嘧啶和动脉化疗与多西他赛导致组织学证实的多个区域皮肤转移超过2年的完全反应。尽管静脉给予多西他赛，但观察到全身性疾病进展缓慢。
Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.