241Am removal by DTPA vs. occurrence of skeletal malignancy.

241Am removal by DTPA vs. occurrence of skeletal malignancy.
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DTPA 去除 241Am 与骨骼恶性肿瘤的发生。

DOI:
10.1097/00004032-199812000-00008
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发表时间:
1998
期刊:
影响因子:
2.2
通讯作者:
Mays,CW
Mays,CW
中科院分区:
医学4区
文献类型:
--
作者:
Lloyd,RD;Taylor,GN;Mays,CW

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Beagle dogs injected with 241 Am and treated subsequently with DTPA exhibited a reduced occurrence of skeletal malignancies and increased lifespans when compared to corresponding untreated animals also given 241 Am. Whereas 92% of dogs given about 11 kBq 241 Am kg− 1 and not treated with DTPA developed bone cancer (skeletal dose about 5.9 Gy), skeletal malignancy was seen in only 40% and 27%, respectively, among two groups of DTPA-treated animals injected with 11 kBq kg− 1 (doses of 5.7 and 1.7 Gy). The median lifespan among the untreated dogs was 1,728 d, but the median lifespans in the DTPA-treated groups were 2,478 and 3,654 d, respectively. Untreated dogs with a skeletal dose averaging about 2 Gy had 53% bone cancer occurrence and a median lifespan of 3,227 d. These data did not enable us to address the question of whether the reduction in cancer occurrence was proportional to, greater than, or less than the reduction in skeletal dose, but the third possibility seems unlikely.
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期刊: The Journal of pharmacology and experimental therapeutics
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