NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA DISTRIBUTION IN HUMAN-BRAIN - NORMAL LEVELS IN BASAL FOREBRAIN IN ALZHEIMERS-DISEASE
NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA DISTRIBUTION IN HUMAN-BRAIN - NORMAL LEVELS IN BASAL FOREBRAIN IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0169-328x(89)90011-9
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
CHAO, MV
中科院分区：
文献类型：
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作者：
GOEDERT, M;FINE, A;CHAO, MV
神经生长因子（NGF）受体mRNA被发现广泛分布在整个人类中枢神经系统，在基底前脑的水平最高，这表明，神经生长因子可能作为基底前脑大细胞胆碱能神经细胞的逆行营养信使。后者的退化构成了阿尔茨海默病的主要特征之一，它可能是导致这种疾病的一些认知障碍的原因。没有证据表明在阿尔茨海默病的基底前脑中NGF受体mRNA的合成不足，其中NGF受体样免疫反应性仅限于神经元细胞体。因此，NGF可能是治疗上有益的。它可能会诱导基底前脑胆碱能细胞肥大，合成更多的胆碱乙酰转移酶，并延长神经突起。
Nerve growth factor (NGF) receptor mRNA was found to be widely distributed throughout the human central nervous system, with the highest levels in the basal forebrain; this suggests that NGF may function as a retrograde trophic messenger for basal forebrain magnocellular cholinergic nerve cells. The degeneration of the latter constitutes one of the main features of Alzheimer''s disease and it may be responsible for some of the cognitive impairment that characterizes the disease. No evidence was obtained for an insufficient synthesis of NGF receptor mRNA in the basal forebrain in Alzheimer''s disease, where NGF receptor-like immunoreactivity was confined to neuronal cell bodies. NGF could thus be therapeutically beneficial. It could be expected to induce basal forebrain cholinergic cells to hypertrophy, synthesize more choline acetyltransferase and extend neurites.