High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease
High Long-Term Cortisol Levels, Measured in Scalp Hair, Are Associated With a History of Cardiovascular Disease
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DOI：
10.1210/jc.2012-3663
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发表时间：
2013-05-01
影响因子：
5.8
通讯作者：
van Rossum, E. F. C.
中科院分区：
文献类型：
--
作者：
Manenschijn, L.;Schaap, L.;van Rossum, E. F. C.
背景：压力与心血管疾病的发病率增加有关。通过测量血清和唾液中的皮质醇，研究了慢性应激对心血管风险的影响，这是仅在1个时间点测量的。这些研究得出了不确定的结果。测量头皮毛发中的皮质醇是一种新方法，它提供了测量长期皮质醇暴露的机会。我们的目的是研究头皮毛发中测量的长期皮质醇水平是否与心血管疾病相关。方法：从一项基于人群的大型队列研究中随机选择了一组283名社区居住老年参与者（中位年龄，75岁;范围，65-85岁）。皮质醇是在3厘米的头发片段中测量的，大致对应于3个月的时间。自我报告的数据有关冠心病，中风，外周动脉疾病，糖尿病，和其他慢性非心血管疾病caseed.Results：头发皮质醇水平显着低于女性比男性（21.0比26.3 pg/mg头发; P <0.001）。高头发皮质醇水平与心血管风险增加（比值比，2.7; P = 0.01）和2型糖尿病风险增加（比值比，3.2; P = 0.04）相关。有头发皮质醇水平和noncardiovascular diseases.Conclusions之间没有关联：长期皮质醇水平升高与心血管疾病史。我们发现的心血管风险增加与传统的心血管危险因素的作用相当，这表明长期升高的皮质醇可能是一个重要的心血管危险因素。
Background: Stress is associated with an increased incidence of cardiovascular disease. The impact of chronic stress on cardiovascular risk has been studied by measuring cortisol in serum and saliva, which are measurements of only 1 time point. These studies yielded inconclusive results. The measurement of cortisol in scalp hair is a novel method that provides the opportunity to measure long-term cortisol exposure. Our aim was to study whether long-term cortisol levels, measured in scalp hair, are associated with cardiovascular diseases.Methods: A group of 283 community-dwelling elderly participants were randomly selected from a large population-based cohort study (median age, 75 y; range, 65-85 y). Cortisol was measured in 3-cm hair segments, corresponding roughly with a period of 3 months. Self-reported data concerning coronary heart disease, stroke, peripheral arterial disease, diabetes mellitus, and other chronic noncardiovascular diseases were collected.Results: Hair cortisol levels were significantly lower in women than in men (21.0 vs 26.3 pg/mg hair; P < .001). High hair cortisol levels were associated with an increased cardiovascular risk (odds ratio, 2.7; P = .01) and an increased risk of type 2 diabetes mellitus (odds ratio, 3.2; P = .04). There were no associations between hair cortisol levels and noncardiovascular diseases.Conclusions: Elevated long-term cortisol levels are associated with a history of cardiovascular disease. The increased cardiovascular risk we found is equivalent to the effect of traditional cardiovascular risk factors, suggesting that long-term elevated cortisol may be an important cardiovascular risk factor.