Effects of common excitatory and inhibitory inputs on motoneuron synchronization.
Effects of common excitatory and inhibitory inputs on motoneuron synchronization.
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常见兴奋性和抑制性输入对运动神经元同步的影响。
DOI：
10.1152/jn.2001.86.6.2807
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Powers,RK
中科院分区：
文献类型：
--
作者：
Turker,KS;Powers,RK
我们通过模拟带有注入电流瞬变的突触输入，比较了常见的兴奋性和抑制性输入对运动神经元同步的影响。我们在大鼠脑干脑片上记录到的舌下运动神经元中，使用阈值以上注入电流阶跃和叠加噪声的组合来模拟生理激活过程中可能发生的突触驱动，从而诱导出重复放电。通过添加一个由6到300串瞬变电流组成的波形来模拟普通输入对运动神经元的影响，该波形旨在模拟兴奋性和/或抑制性突触电流。我们比较了几个试验中获得的放电记录，在这些试验中，在不同的背景噪声波形存在的情况下，重复施加相同的“公共输入”波形。通过编制同一细胞不同时间放电之间的互相关直方图(CCHist)和潜伏期频率图(PSFreq)，确定共同输入对运动神经元放电概率和放电率的影响。兴奋性和抑制性共同输入均可引起同步放电，在CCHist有一个大的中心峰。普通兴奋性输入产生的CCHist具有比普通抑制性输入产生的中心峰更大更窄的特征。一般兴奋性输入产生的PSFreqs表明，运动神经元的放电率在0时左右增加，这与CCHist的窄而大的中心峰相吻合。另一方面，抑制性输入往往在对应于CCHist中小而宽的中心峰的时间附近产生很小的放电率变化，如果有变化的话。这些结果表明，CCHist反映的是净公共投入的有效强度，而不是它的符号。尽管对于净兴奋性和抑制性共同输入，放电速率的相关变化往往有很大不同，但除了在某些限制条件下，PSFreq分析也不能用来明确区分净兴奋和净抑制。
We compared the effects of common excitatory and inhibitory inputs on motoneuron synchronization by simulating synaptic inputs with injected current transients. We elicited repetitive discharge in hypoglossal motoneurons recorded in slices of rat brain stem using a combination of a suprathreshold injected current step with superimposed noise to mimic the synaptic drive likely to occur during physiological activation. The effects of common inputs to motoneurons were simulated by the addition of a waveform composed of from 6 to 300 trains of current transients designed to mimic excitatory and/or inhibitory synaptic currents. We compared the discharge records obtained in several trials in which the same “common input” waveform was applied repeatedly in the presence of different background noise waveforms. The effects of the common input on motoneuron discharge probability and discharge rate were determined by compiling a cross-correlation histogram (CCHist) and a perispike frequencygram (PSFreq) between the discharges of the same cell at different times. Both excitatory and inhibitory common inputs induced synchronous discharge that was evident by a large central peak in the CCHist. The CCHists produced by common excitatory inputs were characterized by larger and narrower central peaks than those generated by common inhibitory inputs. The PSFreqs produced by common excitatory inputs indicated an increase in the discharge rate of motoneurons aroundtime 0that coincided with the narrow and large central peak in the CCHist. On the other hand, inhibitory inputs often generated very little, if any, change in the discharge rate aroundtime 0corresponding with the small and wide central peak in the CCHist. These results suggest that the CCHist indicates the effective strength of the net common input but not its sign. Although correlated changes in discharge rate are often quite different for net excitatory and inhibitory common input, except in some restricted conditions, the PSFreq analysis also cannot be used to unambiguously distinguish net excitation from net inhibition.
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