A primer in cytokines
A primer in cytokines
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DOI：
10.1097/01.bcr.0000150214.72984.44
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Gamelli, RL
中科院分区：
文献类型：
--
作者：
Gosain, A;Gamelli, RL
宿主对损伤或感染的反应是内分泌、代谢和免疫改变的复杂相互作用，旨在促进伤口愈合并使系统恢复到稳态状态。细胞因子是对损伤的炎症反应的主要介质。这篇文章作为这类重要的炎症介质的介绍。主要的促炎和抗炎细胞因子以及趋化因子进行了讨论。从实验室和临床尝试操纵这些介质的结果进行了讨论，并为今后的研究在抗细胞因子治疗的建议。
The host response to injury or infection is a complex interplay of endocrine, metabolic, and immunological alterations designed to promote wound healing and restore the system to a state of homeostasis. Cytokines are the primary mediators of the inflammatory response to injury. This article serves as an introduction to this important class of inflammatory mediators. The major pro- and anti- inflammatory cytokines as well as the chemokines are discussed. Results from laboratory and clinical attempts at manipulation of these mediators are discussed and recommendations for future research in anticytokine therapy are made.